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Tmem253 Gene Detail
Summary
  • Symbol
    Tmem253
  • Name
    transmembrane protein 253
  • Synonyms
    G630016D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588246
    NCBI Gene: 619301
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52253115-52257251 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588246
 protein coding gene Chr14:52252309-52257251 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021288
 protein coding gene Chr14:46028046-46031794 (+)
A/J MGP_AJ_G0021245
 protein coding gene Chr14:44837739-44840637 (+)
AKR/J MGP_AKRJ_G0021221
 protein coding gene Chr14:46450608-46455328 (+)
BALB/cJ MGP_BALBcJ_G0021249
 protein coding gene Chr14:44942820-44945719 (+)
C3H/HeJ MGP_C3HHeJ_G0021029
 protein coding gene Chr14:46262341-46269779 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021688
 protein coding gene Chr14:48064698-48067620 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019233
 protein coding gene Chr14:44030611-44033523 (+)
CAST/EiJ MGP_CASTEiJ_G0020548
 protein coding gene Chr14:43235949-43238853 (+)
CBA/J MGP_CBAJ_G0020996
 protein coding gene Chr14:49529989-49535991 (+)
DBA/2J MGP_DBA2J_G0021117
 protein coding gene Chr14:44600466-44603368 (+)
FVB/NJ MGP_FVBNJ_G0021100
 protein coding gene Chr14:44190465-44193351 (+)
LP/J MGP_LPJ_G0021192
 protein coding gene Chr14:46630875-46634646 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021123
 protein coding gene Chr14:48980801-48985686 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021715
 protein coding gene Chr14:45836952-45840638 (+)
PWK/PhJ MGP_PWKPhJ_G0020297
 protein coding gene Chr14:41355543-41358442 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020124
 protein coding gene Chr14:41872684-41875667 (+)
WSB/EiJ MGP_WSBEiJ_G0020601
 protein coding gene Chr14:46157351-46160302 (+)



Homology
more
  • Human Ortholog
    TMEM253, transmembrane protein 253
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM253, transmembrane protein 253
  • Synonyms
    C14orf176, C14orf95, NCRNA00220
  • Links
    NCBI Gene ID: 643382
    neXtProt AC: NX_P0C7T8
    UniProt: P0C7T8

  • Chr Location
    14q11.2; chr14:21098811-21103724 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    28
  • Targeted
    1
  • Genomic Mutations
    1 involving Tmem253
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    14 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000072571 Ensembl Gene Model | MGI Sequence Detail 4137 C57BL/6J ±  kb
transcript ENSMUST00000100638 Ensembl | MGI Sequence Detail 1234 Not Applicable  
polypeptide ENSMUSP00000098203 Ensembl | MGI Sequence Detail 204 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory