About   Help   FAQ
Tagap Gene Detail
Summary
  • Symbol
    Tagap
  • Name
    T cell activation Rho GTPase activating protein
  • Synonyms
    Tcd-1, Tcd1, Tcd1a, tcs-1, tcs1, TRD
  • Feature Type
    protein coding gene
  • IDs
    MGI:3615484
    NCBI Gene: 72536
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:8144832-8153729 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3615484
 protein coding gene Chr17:8144832-8153729 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023121
 protein coding gene Chr17:5185750-5238253 (+)
A/J MGP_AJ_G0023095
 protein coding gene Chr17:5431374-5440675 (+)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0022856
 protein coding gene Chr17:5327002-5337883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023536
 protein coding gene Chr17:5446352-5456022 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021037
 protein coding gene Chr17:3471875-3480813 (-)
CAST/EiJ MGP_CASTEiJ_G0022367
 protein coding gene Chr17:5139795-5149010 (+)
CBA/J MGP_CBAJ_G0022826
 protein coding gene Chr17:5793682-5805218 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0022932
 protein coding gene Chr17:5007051-5021235 (+)
LP/J MGP_LPJ_G0023024
 protein coding gene Chr17:4289307-4299291 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022951
 protein coding gene Chr17:5571332-5581414 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023561
 protein coding gene Chr17:5307709-5361481 (+)
PWK/PhJ MGP_PWKPhJ_G0022116
 protein coding gene Chr17:4675632-4689630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021941
 protein coding gene Chr17:3922366-3931284 (-)
WSB/EiJ MGP_WSBEiJ_G0022423
 protein coding gene Chr17:5389668-5399200 (+)



Homology
more
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Synonyms
    ARHGAP47, FKSG15, IDDM21, TAGAP1
  • Links
    NCBI Gene ID: 117289
    neXtProt AC: NX_Q8N103
    UniProt: Q8N103

  • Chr Location
    6q25.3; chr6:159034468-159095823 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from multigenic genotypes
    354 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72536 NCBI Gene Model | MGI Sequence Detail 8898 C57BL/6J ±  kb
transcript NM_145968 RefSeq | MGI Sequence Detail 3076 Not Specified  
polypeptide B2RWW0 UniProt | EBI | MGI Sequence Detail 714 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR047886 ARHGAP20-like, RhoGAP domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
  • GlyGen
    B2RWW0 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14737, MGD-MRK-14742, MGD-MRK-14931, MGD-MRK-14934, MGI:98499
References
more
  • Summaries
    All 381
    Diseases 6
    Gene Ontology 4
    Phenotypes 354
  • Earliest
    J:6915 Klein J, et al., H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17. Immunogenetics. 1982;16(4):285-317
  • Latest
    J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory