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Mir378a Gene Detail
Summary
  • Symbol
    Mir378a
  • Name
    microRNA 378a
  • Synonyms
    Mirn378, mmu-mir-378, mmu-mir-378a
  • Feature Type
    miRNA gene
  • IDs
    MGI:3617791
    NCBI Gene: 723889
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61530906-61530971 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3617791
 miRNA gene Chr18:61530906-61530971 (-)
129S1/SvImJ MGP_129S1SvImJ_G0008394
 miRNA gene Chr18:61281253-61281318 (-)
A/J MGP_AJ_G0008383
 miRNA gene Chr18:58648706-58648771 (-)
AKR/J MGP_AKRJ_G0008367
 miRNA gene Chr18:60263943-60264008 (-)
BALB/cJ MGP_BALBcJ_G0008368
 miRNA gene Chr18:58776309-58776374 (-)
C3H/HeJ MGP_C3HHeJ_G0008313
 miRNA gene Chr18:60495968-60496033 (-)
C57BL/6NJ MGP_C57BL6NJ_G0008569
 miRNA gene Chr18:62944136-62944201 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007602
 miRNA gene Chr18:58193492-58193557 (-)
CAST/EiJ MGP_CASTEiJ_G0008175
 miRNA gene Chr18:60369284-60369349 (-)
CBA/J MGP_CBAJ_G0008279
 miRNA gene Chr18:64963242-64963307 (-)
DBA/2J MGP_DBA2J_G0008311
 miRNA gene Chr18:58315119-58315184 (-)
FVB/NJ MGP_FVBNJ_G0008333
 miRNA gene Chr18:57727233-57727298 (-)
LP/J MGP_LPJ_G0008396
 miRNA gene Chr18:61136832-61136897 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0008299
 miRNA gene Chr18:66570870-66570935 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0008558
 miRNA gene Chr18:60459287-60459352 (-)
PWK/PhJ MGP_PWKPhJ_G0008097
 miRNA gene Chr18:58547708-58547773 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007974
 miRNA gene Chr18:60692620-60692685 (-)
WSB/EiJ MGP_WSBEiJ_G0008257
 miRNA gene Chr18:60324986-60325051 (-)



Homology
more
  • Human Ortholog
    MIR378A, microRNA 378a
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR378A, microRNA 378a
  • Synonyms
    hsa-mir-378, hsa-mir-378a, MIR378, MIRN378, miRNA378
  • Links
    NCBI Gene ID: 494327

  • Chr Location
    chr5:149732825-149732890 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to diet-induced obesity with increased energy expenditure and reduced adipose.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      22
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723889 NCBI Gene Model | MGI Sequence Detail 66 C57BL/6J ±  kb
    transcript NR_029879 RefSeq | MGI Sequence Detail 66 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Other 2
    Other Database
    Links
    less
    miRBase MI0000795
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:84906 Dostie J, et al., Numerous microRNPs in neuronal cells containing novel microRNAs. (Erratum: RNA 2003;9(5):631-2). RNA. 2003 Feb;9(2):180-6
    • Latest
      J:351483 Durr AJ, et al., Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1. Am J Physiol Cell Physiol. 2022 Mar 1;322(3):C482-C495
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory