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Mir128-2 Gene Detail
Summary
  • Symbol
    Mir128-2
  • Name
    microRNA 128-2
  • Synonyms
    mir 128b, mir-128b, Mirn128-2, Mirn128b, mmu-mir-128-2, mmu-mir-128b
  • Feature Type
    miRNA gene
  • IDs
    MGI:3618709
    NCBI Gene: 723815
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:111947704-111947779 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 62.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3618709
 miRNA gene Chr9:111947704-111947779 (-)
129S1/SvImJ MGP_129S1SvImJ_G0009244
 miRNA gene Chr9:114381691-114381766 (-)
A/J MGP_AJ_G0009225
 miRNA gene Chr9:110181513-110181588 (-)
AKR/J MGP_AKRJ_G0009214
 miRNA gene Chr9:112949562-112949637 (-)
BALB/cJ MGP_BALBcJ_G0009209
 miRNA gene Chr9:109969339-109969414 (-)
C3H/HeJ MGP_C3HHeJ_G0009150
 miRNA gene Chr9:113455285-113455360 (-)
C57BL/6NJ MGP_C57BL6NJ_G0009451
 miRNA gene Chr9:117514419-117514494 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0008303
 miRNA gene Chr9:107386257-107386332 (-)
CAST/EiJ MGP_CASTEiJ_G0008980
 miRNA gene Chr9:113272350-113272425 (-)
CBA/J MGP_CBAJ_G0009115
 miRNA gene Chr9:121856134-121856209 (-)
DBA/2J MGP_DBA2J_G0009145
 miRNA gene Chr9:109639811-109639886 (-)
FVB/NJ MGP_FVBNJ_G0009163
 miRNA gene Chr9:108475895-108475970 (-)
LP/J MGP_LPJ_G0009242
 miRNA gene Chr9:114679717-114679792 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0009129
 miRNA gene Chr9:123120065-123120140 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0009421
 miRNA gene Chr9:113294049-113294124 (-)
PWK/PhJ MGP_PWKPhJ_G0008905
 miRNA gene Chr9:109895818-109895893 (-)
SPRET/EiJ MGP_SPRETEiJ_G0008744
 miRNA gene Chr9:113413937-113414012 (-)
WSB/EiJ MGP_WSBEiJ_G0009074
 miRNA gene Chr9:113176573-113176648 (-)



Homology
more
  • Human Ortholog
    MIR128-2, microRNA 128-2
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR128-2, microRNA 128-2
  • Synonyms
    mir-128-2, mir-128b, MIR128B, MIRN128-2, MIRN128B
  • Links
    NCBI Gene ID: 406916

  • Chr Location
    chr3:35744476-35744559 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased vertical activity, juvenile hyperactivity that progresses rapidly to severe seizures, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    39
  • Literature Summary
    12
Sequences &
Gene Models
less
  • All Sequences
    23
  • RefSeq
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 723815 NCBI Gene Model | MGI Sequence Detail 76 C57BL/6J ±  kb
transcript NR_029823 RefSeq | MGI Sequence Detail 76 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 8
    Primer pair 3
    Other 5
Other Database
Links
less
miRBase MI0000726
References
more
  • Summaries
    All 27
    Developmental Gene Expression 12
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:101078 Smirnova L, et al., Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005 Mar;21(6):1469-77
  • Latest
    J:305608 Wang P, et al., miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus. Biochem Biophys Res Commun. 2021 Mar 19;545:195-202
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory