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Phenotypes Associated with This Genotype
Genotype
MGI:3624989
Allelic
Composition		 Prdm9tm1Ymat/Prdm9tm1Ymat
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9tm1Ymat mutation (3 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian folliculogenesis ( J:102875 )
• at 5 weeks of age no growing follicles at any stage of development are seen
decreased testis weight ( J:102875 )
• at 8 weeks of age, testis weigh 75% less than in wild-type mice
decreased oocyte number ( J:102875 )
• from E17.5 the number of germ cells is decreased with few present in neonates
abnormal chromosomal synapsis ( J:102875 )
• deficient pairing of homologous chromosomes
abnormal female meiosis ( J:102875 )
• meitotic arrest with impaired homologous chromosome pairing and sex body formation
• pachytene chromosomes are frequently branched and connected to other chromosomes
arrest of male meiosis ( J:102875 )
• meitotic arrest with impaired homologous chromosome pairing and sex body formation
• pachytene chromosomes are frequently branched and connected to other chromosomes

endocrine/exocrine glands
abnormal ovarian folliculogenesis ( J:102875 )
• at 5 weeks of age no growing follicles at any stage of development are seen
decreased testis weight ( J:102875 )
• at 8 weeks of age, testis weigh 75% less than in wild-type mice

cellular
decreased oocyte number ( J:102875 )
• from E17.5 the number of germ cells is decreased with few present in neonates
abnormal chromosomal synapsis ( J:102875 )
• deficient pairing of homologous chromosomes
abnormal female meiosis ( J:102875 )
• meitotic arrest with impaired homologous chromosome pairing and sex body formation
• pachytene chromosomes are frequently branched and connected to other chromosomes
arrest of male meiosis ( J:102875 )
• meitotic arrest with impaired homologous chromosome pairing and sex body formation
• pachytene chromosomes are frequently branched and connected to other chromosomes
abnormal double-strand DNA break repair ( J:102875 )
• germ cells show impaired double strand break repair compared to wild-type

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:102875 )
• germ cells show impaired double strand break repair compared to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory