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Misfa Gene Detail
Summary
  • Symbol
    Misfa
  • Name
    mitochondrial sheath formation associated
  • Synonyms
    Gm9999, Kastor, Polluks
Location &
Maps
more
  • Sequence Map
    Chr7:46633328-46637551 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3642801
 protein coding gene Chr7:46626380-46637551 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032278
 protein coding gene Chr7:47401159-47405382 (+)
A/J MGP_AJ_G0032257
 protein coding gene Chr7:46410806-46415029 (+)
AKR/J MGP_AKRJ_G0032193
 protein coding gene Chr7:47731658-47735881 (+)
BALB/cJ MGP_BALBcJ_G0032269
 protein coding gene Chr7:46419379-46423602 (+)
C3H/HeJ MGP_C3HHeJ_G0031982
 protein coding gene Chr7:48201588-48205811 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032759
 protein coding gene Chr7:49673760-49677983 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029775
 protein coding gene Chr7:48951370-48955810 (+)
CAST/EiJ MGP_CASTEiJ_G0031310
 protein coding gene Chr7:39677782-39682019 (+)
CBA/J MGP_CBAJ_G0031947
 protein coding gene Chr7:51336213-51340435 (+)
DBA/2J MGP_DBA2J_G0032104
 protein coding gene Chr7:46087479-46091702 (+)
FVB/NJ MGP_FVBNJ_G0032058
 protein coding gene Chr7:45905087-45909307 (+)
LP/J MGP_LPJ_G0032185
 protein coding gene Chr7:48107295-48111518 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032095
 protein coding gene Chr7:49957789-49962012 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032776
 protein coding gene Chr7:46933140-46937363 (+)
PWK/PhJ MGP_PWKPhJ_G0031035
 protein coding gene Chr7:39469957-39474346 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030873
 protein coding gene Chr7:34957197-34961440 (+)
WSB/EiJ MGP_WSBEiJ_G0031430
 protein coding gene Chr7:47455117-47459348 (+)



Homology
more
  • Human Ortholog
    MISFA, mitochondrial sheath formation associated
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MISFA, mitochondrial sheath formation associated
  • Synonyms
    Kastor, Polluks, SPTY2D1-AS1, SPTY2D1OS
  • Links
    NCBI Gene ID: 100506540
    UniProt: A0A0U1RRN3

  • Chr Location
    chr11:18588781-18610255 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele lacking both the Kastor and Polluks polypeptides exhibit severely reduced male fertility, asthenozoospermia, decreased fertilization frequency, and abnormal sperm mitochondrial sheath morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      34
    • RefSeq
      1
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056509 Ensembl Gene Model | MGI Sequence Detail 4224 C57BL/6J ±  kb
    transcript ENSMUST00000188312 Ensembl | MGI Sequence Detail 404 Not Applicable  
    polypeptide ENSMUSP00000156094 Ensembl | MGI Sequence Detail 53 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:7380603
    References
    more
    • Summaries
      All 15
      Gene Ontology 3
      Phenotypes 1
    • Earliest
      J:332977 Mise S, et al., Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nat Commun. 2022 Feb 28;13(1):1071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory