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Vmn2r53 Gene Detail
Summary
  • Symbol
    Vmn2r53
  • Name
    vomeronasal 2, receptor 53
  • Synonyms
    EG637908
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644480
    NCBI Gene: 637908
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:12315397-12342583 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 7.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    686 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644480
 protein coding gene Chr7:12296778-12342715 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031648
 protein coding gene Chr7:9953558-9983474 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0031545
 protein coding gene Chr7:10020686-10045730 (-)
BALB/cJ MGP_BALBcJ_G0031627
 protein coding gene Chr7:9917846-9940070 (-)
C3H/HeJ MGP_C3HHeJ_G0031350
 protein coding gene Chr7:10126736-10151780 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032090
 protein coding gene Chr7:10523922-10539494 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031306
 protein coding gene Chr7:10672856-10693020 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0031419
 protein coding gene Chr7:9688171-9709235 (-)
LP/J MGP_LPJ_G0031550
 protein coding gene Chr7:10018606-10044445 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031455
 protein coding gene Chr7:10787111-10810415 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032120
 protein coding gene Chr7:9903922-9930407 (-)
PWK/PhJ MGP_PWKPhJ_G0030435
 protein coding gene Chr7:8165853-8181354 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased aggression towards male after being primed for aggression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 637908 NCBI Gene Model | MGI Sequence Detail 27187 C57BL/6J ±  kb
transcript NM_001104644 RefSeq | MGI Sequence Detail 2637 C57BL/6  
polypeptide NP_001098114 RefSeq | MGI Sequence Detail 878 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-related
    IPR011500 GPCR, family 3, nine cysteines domain
    IPR038550 GPCR, family 3, nine cysteines domain superfamily
    IPR004073 GPCR, family 3, vomeronasal receptor, type 2
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1
References
more
  • Summaries
    All 9
    Gene Ontology 1
    Phenotypes 1
  • Earliest
    J:125082 Young JM, et al., V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Trends Genet. 2007 May;23(5):212-5
  • Latest
    J:327623 Itakura T, et al., A single vomeronasal receptor promotes intermale aggression through dedicated hypothalamic neurons. Neuron. 2022 Aug 3;110(15):2455-2469.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory