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Cbr1b Gene Detail
Summary
  • Symbol
    Cbr1b
  • Name
    carbonyl reductase 1B
  • Synonyms
    Gm5678
Location &
Maps
more
  • Sequence Map
    Chr16:93424985-93427339 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 54.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    419 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646098
 protein coding gene Chr16:93424872-93427351 (+)
129S1/SvImJ MGP_129S1SvImJ_G0040112
 pseudogene Chr16:94818998-94821300 (+)
A/J MGP_AJ_G0040109
 pseudogene Chr16:90343891-90400974 (+)
AKR/J MGP_AKRJ_G0040035
 pseudogene Chr16:93096408-93098670 (+)
BALB/cJ MGP_BALBcJ_G0040091
 pseudogene Chr16:90874232-90877025 (+)
C3H/HeJ MGP_C3HHeJ_G0039743
 pseudogene Chr16:93614292-93616559 (+)
C57BL/6NJ MGP_C57BL6NJ_G0040686
 pseudogene Chr16:97801340-97808391 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0038833
 pseudogene Chr16:94327992-94330240 (+)
CBA/J MGP_CBAJ_G0039710
 pseudogene Chr16:102040465-102042731 (+)
DBA/2J MGP_DBA2J_G0039902
 pseudogene Chr16:90237017-90291413 (+)
FVB/NJ MGP_FVBNJ_G0039864
 pseudogene Chr16:89374233-89446113 (+)
LP/J MGP_LPJ_G0039951
 pseudogene Chr16:94489853-94492162 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0039851
 pseudogene Chr16:106441099-106445103 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0040777
 pseudogene Chr16:93605952-93636815 (+)
PWK/PhJ MGP_PWKPhJ_G0038526
 pseudogene Chr16:90506005-90508495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0038241
 pseudogene Chr16:93175589-93178832 (+)
WSB/EiJ MGP_WSBEiJ_G0039060
 pseudogene Chr16:93884473-93886762 (+)



Homology
more
  • Human Ortholog
    CBR1, carbonyl reductase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBR1, carbonyl reductase 1
  • Synonyms
    CBR, hCBR1, PG-9-KR, SDR21C1
  • Links
    NCBI Gene ID: 873
    neXtProt AC: NX_P16152
    UniProt: P16152

  • Chr Location
    21q22.12; chr21:36069941-36073166 (+)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
  • All Sequences
    23
  • RefSeq
    1
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000082815 Ensembl Gene Model | MGI Sequence Detail 2355 C57BL/6J ±  kb
transcript ENSMUST00000120115 Ensembl | MGI Sequence Detail 939 Not Applicable  
polypeptide ENSMUSP00000147517 Ensembl | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    1.1.1.184
  • InterPro Domains
    IPR045313 Carbonyl reductase [NADPH] 1-like
    IPR036291 NAD(P)-binding domain superfamily
    IPR002347 Short-chain dehydrogenase/reductase SDR
Other
Accession IDs
less
MGI:7484386
References
more
  • Summaries
    All 72
    Diseases 4
    Gene Ontology 3
    Phenotypes 64
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory