Agbl1 MGI Mouse Gene Detail - MGI:3646469 - ATP/GTP binding protein-like 1

Symbol

Agbl1
Name

ATP/GTP binding protein-like 1
Synonyms

Ccp4, EG244071, Nna1-l1

Feature Type

protein coding gene
IDs

MGI:3646469
NCBI Gene: 244071
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:75879635-76774446 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 43.87 cM
Mapping Data

1 experiment

SNPs within 2kb

25168 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3646469	protein coding gene	Chr7:75879311-76774446 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032376	protein coding gene	Chr7:77948846-78886772 (+)
A/J	MGP_AJ_G0032355	protein coding gene	Chr7:76166033-77097517 (+)
AKR/J	MGP_AKRJ_G0032291	protein coding gene	Chr7:77798531-78737177 (+)
BALB/cJ	MGP_BALBcJ_G0032367	protein coding gene	Chr7:75925583-76824720 (+)
C3H/HeJ	MGP_C3HHeJ_G0032080	protein coding gene	Chr7:78476084-79398905 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032859	protein coding gene	Chr7:81109181-82075099 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029867	protein coding gene	Chr7:78890914-79733388 (+)
CAST/EiJ	MGP_CASTEiJ_G0031408	protein coding gene	Chr7:69348287-70277055 (+)
CBA/J	MGP_CBAJ_G0032046	protein coding gene	Chr7:83703550-84746991 (+)
DBA/2J	MGP_DBA2J_G0032201	protein coding gene	Chr7:74779007-75677574 (+)
FVB/NJ	MGP_FVBNJ_G0032156	protein coding gene	Chr7:74773398-75640699 (+)
LP/J	MGP_LPJ_G0032282	protein coding gene	Chr7:79173460-80137121 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032193	protein coding gene	Chr7:83860027-84941323 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032877	protein coding gene	Chr7:77260103-78219078 (+)
PWK/PhJ	MGP_PWKPhJ_G0031128	protein coding gene	Chr7:67946927-68852742 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030969	protein coding gene	Chr7:64249817-65180244 (+)
WSB/EiJ	MGP_WSBEiJ_G0031526	protein coding gene	Chr7:77586791-78518339 (+)

Human Ortholog

AGBL1, AGBL carboxypeptidase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGBL1, AGBL carboxypeptidase 1
Synonyms

CCP4, FECD8
Links

HGNC:26504

NCBI Gene ID: 123624

neXtProt AC: NX_Q96MI9

UniProt: Q96MI9
Chr Location

15q25.3; chr15:86079620-87049169 (+) GRCh38

MGI Vertebrate Homology

Agbl1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: AGBL1
Gene Tree

Agbl1

Diseases

1 with human AGBL1 associations

				Human Disease	Mouse Models
				Fuchs' endothelial dystrophy IDs Fuchs' endothelial dystrophy DOID:11555 ICD10CM:H18.51 MESH:D005642 NCI:C84721 OMIM:136800 OMIM:610158 OMIM:613267 OMIM:613268 OMIM:613269 OMIM:613270 OMIM:613271 OMIM:615523 ORDO:98974 UMLS_CUI:C0016781

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Agbl1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

38
cDNA Data

4
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase agbl1

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All Sequences

37
RefSeq

6
UniProt

2
CCDS

CCDS21370.2, CCDS85321.1

Ensembl

ENSMUSG00000025754 (Evidence)
NCBI Gene

244071

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025754	Ensembl Gene Model \| MGI Sequence Detail	894812	C57BL/6J	± kb
transcript	ENSMUST00000156166	Ensembl \| MGI Sequence Detail	3369	Not Applicable
polypeptide	ENSMUSP00000119721	Ensembl \| MGI Sequence Detail	1122	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003823 cytosolic carboxypeptidase 4

(term hierarchy)
EC

3.4.17.-, 3.4.17.24
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR033852 Cytosolic aminopeptidase 1/4

IPR050821 Cytosolic carboxypeptidase

IPR040626 Cytosolic carboxypeptidase, N-terminal

IPR000834 Peptidase M14, carboxypeptidase A

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All nucleic 8

Genomic 2

cDNA 4

Primer pair 2

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 17
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Agbl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67294	Chr7:75879517-75879542 (+)	-105 bp
Tssr67295	Chr7:75879603-75879614 (+)	-26 bp
Tssr67296	Chr7:76107033-76107036 (+)	227,400 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24