About   Help   FAQ
Fscb Gene Detail
Summary
  • Symbol
    Fscb
  • Name
    fibrous sheath CABYR binding protein
  • Synonyms
    EG623046
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646964
    NCBI Gene: 623046
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:64518104-64521464 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 26.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646964
 protein coding gene Chr12:64518104-64521672 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019774
 protein coding gene Chr12:63935184-63938785 (-)
A/J MGP_AJ_G0019733
 protein coding gene Chr12:61566076-61569677 (-)
AKR/J MGP_AKRJ_G0019708
 protein coding gene Chr12:63530024-63533445 (-)
BALB/cJ MGP_BALBcJ_G0019713
 protein coding gene Chr12:62017718-62021319 (-)
C3H/HeJ MGP_C3HHeJ_G0019518
 protein coding gene Chr12:63855941-63859542 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020165
 protein coding gene Chr12:65933119-65936756 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017785
 protein coding gene Chr12:59403900-59407533 (-)
CAST/EiJ MGP_CASTEiJ_G0019070
 protein coding gene Chr12:58587565-58591166 (-)
CBA/J MGP_CBAJ_G0019487
 protein coding gene Chr12:68331607-68335208 (-)
DBA/2J MGP_DBA2J_G0019603
 protein coding gene Chr12:61494252-61497817 (-)
FVB/NJ MGP_FVBNJ_G0019591
 protein coding gene Chr12:60558353-60561954 (-)
LP/J MGP_LPJ_G0019675
 protein coding gene Chr12:63937161-63940762 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019629
 protein coding gene Chr12:71153868-71157469 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020199
 protein coding gene Chr12:62920336-62923937 (-)
PWK/PhJ MGP_PWKPhJ_G0018836
 protein coding gene Chr12:55748075-55781943 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018630
 protein coding gene Chr12:57213599-57248857 (-)
WSB/EiJ MGP_WSBEiJ_G0019121
 protein coding gene Chr12:63427324-63430889 (-)



Homology
more
  • Human Ortholog
    FSCB, fibrous sheath CABYR binding protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSCB, fibrous sheath CABYR binding protein
  • Synonyms
    C14orf155
  • Links
    NCBI Gene ID: 84075
    neXtProt AC: NX_Q5H9T9
    UniProt: Q5H9T9

  • Chr Location
    14q21.2; chr14:44504149-44507283 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    19
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043060 Ensembl Gene Model | MGI Sequence Detail 3361 C57BL/6J ±  kb
    transcript ENSMUST00000059833 Ensembl | MGI Sequence Detail 3361 Not Applicable  
    polypeptide ENSMUSP00000051554 Ensembl | MGI Sequence Detail 1062 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 19
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:128382 Li YF, et al., FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. J Biol Chem. 2007 Nov 23;282(47):34104-19
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory