Skint6 MGI Mouse Gene Detail - MGI:3649262 - selection and upkeep of intraepithelial T cells 6

Skint6 Gene Detail

Sequence Map

Chr4:112661813-113144170 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

For selected strains:

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Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

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			Length	Strain/Species	Flank
genomic	230622	NCBI Gene Model \| MGI Sequence Detail	482358	C57BL/6J	± kb
transcript	NM_001103199	RefSeq \| MGI Sequence Detail	3824	C57BL/6
polypeptide	A7XUZ6	UniProt \| EBI \| MGI Sequence Detail	1240	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015957 selection and upkeep of intraepithelial T-cells protein 6

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR050504 Immunoglobulin superfamily BTN/MOG domain-containing protein

IPR013106 Immunoglobulin V-set domain
GlyGen

A7XUZ6 3 sites

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Summaries

All 19

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 8
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:323863 McKenzie DR, et al., Normality sensing licenses local T cells for innate-like tissue surveillance. Nat Immunol. 2022 Mar;23(3):411-422

TSS for Skint6:

(View these features in JBrowse)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24