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Prcd Gene Detail
Summary
  • Symbol
    Prcd
  • Name
    photoreceptor disc component
  • Synonyms
    Gm11744
  • Feature Type
    protein coding gene
  • IDs
    MGI:3649529
    NCBI Gene: 100038570
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116544603-116559224 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.46 cM
Strain
Comparison
more
  • SNPs within 2kb
    494 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3649529
 protein coding gene Chr11:116544360-116559224 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019435
 protein coding gene Chr11:120798986-120814770 (+)
A/J MGP_AJ_G0019403
 protein coding gene Chr11:115508383-115523749 (+)
AKR/J MGP_AKRJ_G0019374
 protein coding gene Chr11:118944850-118966522 (+)
BALB/cJ MGP_BALBcJ_G0019378
 protein coding gene Chr11:115904648-115919866 (+)
C3H/HeJ MGP_C3HHeJ_G0019184
 protein coding gene Chr11:119304674-119322793 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019827
 protein coding gene Chr11:124493782-124511995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017451
 protein coding gene Chr11:112521732-112535777 (+)
CAST/EiJ MGP_CASTEiJ_G0018739
 protein coding gene Chr11:120681087-120696226 (+)
CBA/J MGP_CBAJ_G0019155
 protein coding gene Chr11:129410686-129426295 (+)
DBA/2J MGP_DBA2J_G0019267
 protein coding gene Chr11:114934192-114949111 (+)
FVB/NJ MGP_FVBNJ_G0019259
 protein coding gene Chr11:114444992-114462467 (+)
LP/J MGP_LPJ_G0019337
 protein coding gene Chr11:121182415-121198571 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019292
 protein coding gene Chr11:128443109-128458120 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019866
 protein coding gene Chr11:119608752-119623239 (+)
PWK/PhJ MGP_PWKPhJ_G0018503
 protein coding gene Chr11:116262272-116277306 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018296
 protein coding gene Chr11:119359570-119373929 (+)
WSB/EiJ MGP_WSBEiJ_G0018791
 protein coding gene Chr11:119576889-119592325 (+)



Homology
more
  • Human Ortholog
    PRCD, photoreceptor disc component
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRCD, photoreceptor disc component
  • Synonyms
    RP36
  • Links
    NCBI Gene ID: 768206
    neXtProt AC: NX_Q00LT1
    UniProt: Q00LT1

  • Chr Location
    17q25.1; chr17:76527586-76553580 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRCD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a defect in photoreceptor disc morphogenesis resulting in vesicle accumulation in the inter-photoreceptor space and a slow progressive retinal rod cell degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    4
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100038570 NCBI Gene Model | MGI Sequence Detail 14622 C57BL/6J ±  kb
    transcript NM_001163318 RefSeq | MGI Sequence Detail 816 C57BL/6  
    polypeptide Q00LT2 UniProt | EBI | MGI Sequence Detail 53 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:303922 Remez L, et al., TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments. Int J Mol Sci. 2020 Nov 17;21(22):8677
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory