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Spint3 Gene Detail
Summary
  • Symbol
    Spint3
  • Name
    serine peptidase inhibitor, Kunitz type, 3
  • Synonyms
    Gm14315
  • Feature Type
    protein coding gene
  • IDs
    MGI:3651470
    NCBI Gene: 629747
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164411641-164415355 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.20 cM
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3651470
 protein coding gene Chr2:164411615-164415379 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026858
 protein coding gene Chr2:170025016-170028758 (-)
A/J MGP_AJ_G0026824
 protein coding gene Chr2:163101737-163105816 (-)
AKR/J MGP_AKRJ_G0026795
 protein coding gene Chr2:167942274-167948190 (-)
BALB/cJ MGP_BALBcJ_G0026833
 protein coding gene Chr2:163462432-163466169 (-)
C3H/HeJ MGP_C3HHeJ_G0026575
 protein coding gene Chr2:168298743-168302232 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027281
 protein coding gene Chr2:174965935-174969520 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024651
 protein coding gene Chr2:156506503-156510233 (-)
CAST/EiJ MGP_CASTEiJ_G0026035
 protein coding gene Chr2:168727145-168730810 (-)
CBA/J MGP_CBAJ_G0026552
 protein coding gene Chr2:181299837-181306089 (-)
DBA/2J MGP_DBA2J_G0026690
 protein coding gene Chr2:162271418-162274960 (-)
FVB/NJ MGP_FVBNJ_G0026656
 protein coding gene Chr2:160690790-160694173 (-)
LP/J MGP_LPJ_G0026793
 protein coding gene Chr2:170109627-170113496 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026676
 protein coding gene Chr2:184881280-184884552 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027337
 protein coding gene Chr2:167846371-167849888 (-)
PWK/PhJ MGP_PWKPhJ_G0025772
 protein coding gene Chr2:161866723-161870595 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025573
 protein coding gene Chr2:166735569-166741781 (-)
WSB/EiJ MGP_WSBEiJ_G0026106
 protein coding gene Chr2:168716467-168721157 (-)



Homology
more
  • Human Ortholog
    SPINT3, serine peptidase inhibitor, Kunitz type 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINT3, serine peptidase inhibitor, Kunitz type 3
  • Synonyms
    HKIB9
  • Links
    NCBI Gene ID: 10816
    neXtProt AC: NX_P49223
    UniProt: P49223

  • Chr Location
    chr20:45512461-45515622 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for a null allele exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 629747 NCBI Gene Model | MGI Sequence Detail 3715 C57BL/6J ±  kb
transcript NM_001177401 RefSeq | MGI Sequence Detail 507 C57BL/6  
polypeptide NP_001170872 RefSeq | MGI Sequence Detail 88 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR050098 Kunitz-type Serine Protease Inhibitor
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4
References
more
  • Summaries
    All 16
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:295177 Robertson MJ, et al., Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. BMC Biol. 2020 Aug 19;18(1):103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory