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Niban3 Gene Detail
Summary
  • Symbol
    Niban3
  • Name
    niban apoptosis regulator 3
  • Synonyms
    Bcnp1, Fam129c
  • Feature Type
    protein coding gene
  • IDs
    MGI:3686743
    NCBI Gene: 100037278
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:72050292-72060580 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    273 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3686743
 protein coding gene Chr8:72049000-72061599 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033757
 protein coding gene Chr8:72008992-72021009 (+)
A/J MGP_AJ_G0033740
 protein coding gene Chr8:69072282-69082566 (+)
AKR/J MGP_AKRJ_G0033666
 protein coding gene Chr8:71106437-71117730 (+)
BALB/cJ MGP_BALBcJ_G0033736
 protein coding gene Chr8:69243953-69255807 (+)
C3H/HeJ MGP_C3HHeJ_G0033446
 protein coding gene Chr8:71694019-71703649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034254
 protein coding gene Chr8:74748686-74760804 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031196
 protein coding gene Chr8:63706817-63718288 (+)
CAST/EiJ MGP_CASTEiJ_G0032771
 protein coding gene Chr8:71152248-71162752 (+)
CBA/J MGP_CBAJ_G0033424
 protein coding gene Chr8:77399139-77408622 (+)
DBA/2J MGP_DBA2J_G0033578
 protein coding gene Chr8:68801058-68810869 (+)
FVB/NJ MGP_FVBNJ_G0033520
 protein coding gene Chr8:67888586-67898586 (+)
LP/J MGP_LPJ_G0033665
 protein coding gene Chr8:71982096-71993339 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033567
 protein coding gene Chr8:79941192-79952768 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034271
 protein coding gene Chr8:71177868-71188909 (+)
PWK/PhJ MGP_PWKPhJ_G0032478
 protein coding gene Chr8:68085199-68095813 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032315
 protein coding gene Chr8:70122371-70132220 (+)
WSB/EiJ MGP_WSBEiJ_G0032887
 protein coding gene Chr8:71521578-71533878 (+)



Homology
more
  • Human Ortholog
    NIBAN3, niban apoptosis regulator 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NIBAN3, niban apoptosis regulator 3
  • Synonyms
    BCNP1, FAM129C
  • Links
    NCBI Gene ID: 199786
    neXtProt AC: NX_Q86XR2
    UniProt: Q86XR2

  • Chr Location
    19p13.11; chr19:17523301-17555537 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show impaired B-cell maturation, a reduction of B-1a cells, enhanced survival and proliferation of spleen B cells in response to stimulation, enhanced humoral immune responses, elevated levels of serum IgM and IgG3 antibodies and B-cell expansion in lymphoid organs.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043243 Ensembl Gene Model | MGI Sequence Detail 10289 C57BL/6J ±  kb
    transcript ENSMUST00000143662 Ensembl | MGI Sequence Detail 2267 Not Applicable  
    polypeptide ENSMUSP00000123432 Ensembl | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:6393852
    References
    more
    • Summaries
      All 20
      Phenotypes 9
    • Earliest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory