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Tgfbr3l Gene Detail
Summary
  • Symbol
    Tgfbr3l
  • Name
    transforming growth factor, beta receptor III-like
  • Synonyms
    Gm14378, LOC100039590
  • Feature Type
    protein coding gene
  • IDs
    MGI:3833469
    NCBI Gene: 100044509
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:4298214-4301423 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.99 cM
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3833469
 protein coding gene Chr8:4297994-4301528 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033329
 protein coding gene Chr8:1233599-1236808 (+)
A/J MGP_AJ_G0033310
 protein coding gene Chr8:1182899-1186108 (+)
AKR/J MGP_AKRJ_G0033241
 protein coding gene Chr8:1218104-1221313 (+)
BALB/cJ MGP_BALBcJ_G0033310
 protein coding gene Chr8:1235990-1239190 (+)
C3H/HeJ MGP_C3HHeJ_G0033024
 protein coding gene Chr8:1227964-1231173 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033822
 protein coding gene Chr8:1272847-1276056 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030794
 protein coding gene Chr8:1057279-1060972 (+)
CAST/EiJ MGP_CASTEiJ_G0032348
 protein coding gene Chr8:1111753-1114964 (+)
CBA/J MGP_CBAJ_G0032997
 protein coding gene Chr8:1312127-1315336 (+)
DBA/2J MGP_DBA2J_G0033151
 protein coding gene Chr8:1143175-1146384 (+)
FVB/NJ MGP_FVBNJ_G0033098
 protein coding gene Chr8:1182493-1185702 (+)
LP/J MGP_LPJ_G0033245
 protein coding gene Chr8:1153737-1156946 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033133
 protein coding gene Chr8:1287375-1290584 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033839
 protein coding gene Chr8:1201740-1204940 (+)
PWK/PhJ MGP_PWKPhJ_G0032059
 protein coding gene Chr8:1107735-1110944 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031902
 protein coding gene Chr8:1122976-1126219 (+)
WSB/EiJ MGP_WSBEiJ_G0032462
 protein coding gene Chr8:1181281-1184481 (+)



Homology
more
  • Human Ortholog
    TGFBR3L, transforming growth factor beta receptor 3 like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGFBR3L, transforming growth factor beta receptor 3 like
  • Synonyms
    GEMP, TGFR-3L
  • Links
    NCBI Gene ID: 100507588
    neXtProt AC: NX_H3BV60
    UniProt: H3BV60

  • Chr Location
    chr19:7914830-7919097 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased liter size, oocyte numbers, and serum follicle stimulating hormone levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    5
  • cDNA Data
    1
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000089736 Ensembl Gene Model | MGI Sequence Detail 3210 C57BL/6J ±  kb
    transcript ENSMUST00000110993 Ensembl | MGI Sequence Detail 1075 Not Applicable  
    polypeptide ENSMUSP00000106621 Ensembl | MGI Sequence Detail 297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 1
      Primer pair 1
    References
    more
    • Summaries
      All 15
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:298990 Sah RK, et al., Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory