Plvap<tm1e(EUCOMM)Hmgu> Targeted Allele Detail MGI Mouse (MGI:4434827)

Plvap^{tm1e(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

Symbol:	Plvap^{tm1e(EUCOMM)Hmgu}
Name:	plasmalemma vesicle associated protein; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:4434827
Gene:	Plvap Location: Chr8:71950409-71964396 bp, - strand Genetic Position: Chr8, 34.43 cM
Alliance:	Plvap^{tm1e(EUCOMM)Hmgu} page
IMPC:	Plvap gene page

Mutation
origin

Mutant Cell Lines:	HEPD0550_4_A09, HEPD0550_4_A10, HEPD0550_4_A11, HEPD0550_4_A12, HEPD0550_4_B11, HEPD0550_4_B12, HEPD0550_4_C09, HEPD0550_4_C11, HEPD0550_4_C12, HEPD0550_4_D09, HEPD0550_4_D10, HEPD0550_4_D11, HEPD0550_4_D12, HEPD0550_4_E09, HEPD0550_4_E11, HEPD0550_4_E12, HEPD0550_4_F10, HEPD0550_4_F11, HEPD0550_4_F12, HEPD0550_4_G09, HEPD0550_4_G11, HEPD0550_4_G12, HEPD0550_4_H09, HEPD0550_4_H10, HEPD0550_4_H11
Germline Transmission:	Earliest citation of germline transmission: J:203907
Parent Cell Line:	JM8A1.N3 (ES Cell)
Strain of Origin:	C57BL/6N-A^tm1Brd
Project Collection:	EUCOMM

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutation:		Insertion Vector: L1L2_Bact_P
		Mutation details: The L1L2_Bact_P cassette was inserted at position 71961688 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065, J:203907)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 1 line available
Carrying any Plvap Mutation:	48 strains or lines available

Notes

Cell line HEPD0550_4_E12 was successfully used to make chimeric mice. Germline transmission was accomplished. J:203907

References

Original:	J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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