Dusp4<tm1Jmol> Targeted Allele Detail MGI Mouse (MGI:4456264)

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Dusp4^tm1Jmol
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Dusp4^tm1Jmol
Name:	dual specificity phosphatase 4; targeted mutation 1, Jeffery D Molkentin
MGI ID:	MGI:4456264
Synonyms:	Mkp2^-
Gene:	Dusp4 Location: Chr8:35274451-35287048 bp, + strand Genetic Position: Chr8, 21.16 cM
Alliance:	Dusp4^tm1Jmol page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:140567
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Not Specified
		Mutation details: Exons 2 and 3 were replaced with a neomycin cassette via homologous recombination. RT-PCR confirmed the absence of transcript expression in the heart. (J:140567, J:200367)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Dusp4 Mutation:	23 strains or lines available

References

Original:	J:140567 Ramesh S, et al., TGFbeta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO Rep. 2008 Oct;9(10):990-7
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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