Col4a1<D456> Radiation induced Allele Detail MGI Mouse (MGI:4822198)

Col4a1^D456
Radiation induced Allele Detail

Summary

Symbol:	Col4a1^D456
Name:	collagen, type IV, alpha 1; radiation induced mutation D456
MGI ID:	MGI:4822198
Gene:	Col4a1 Location: Chr8:11248423-11362826 bp, - strand Genetic Position: Chr8, 5.53 cM
Alliance:	Col4a1^D456 page

Mutation
origin

Strain of Origin:

DBA/2

Mutation
description

Allele Type:		Radiation induced
Mutation:		Single point mutation
		Mutation details: Male mice were exposed to two doses of 3 Gy of gamma radiation. This resulted in a G to A nucleotide replacement at position 2991 (NCBI accession # NM_009931) and a glycine to arginine substitution at amiono acid residue 954. (J:163225)
Inheritance:		Dominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Col4a1 Mutation:	78 strains or lines available

References

Original:	J:163517 Favor J, et al., Radiation-induced forward and reverse specific locus mutations and dominant cataract mutations in treated strain BALB/c and DBA/2 male mice. Mutat Res. 1987 Mar;177(1):161-9
All:	2 reference(s)

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