Foxn1<nu-2J> Spontaneous Allele Detail MGI Mouse (MGI:5464997)

Foxn1^nu-2J
Spontaneous Allele Detail

Summary

Symbol:	Foxn1^nu-2J
Name:	forkhead box N1; nude 2 Jackson
MGI ID:	MGI:5464997
Gene:	Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
Alliance:	Foxn1^nu-2J page

Mutation
origin

Strain of Origin:

Mutation
description

Allele Type:		Spontaneous
Mutation:		Intragenic deletion
		Mutation details: This spontaneous mutation, which fails to complement the original nude mutation, has a 7 nucleotide deletion encompassing chromosome 11 nucleotides 78,371,200-206 (GRCm38). This causes a frameshift that leads to the introduction of 186 novel amino acids beginning at residue 114 and then an early termination codon within the forkhead DNA binding domain. (J:192383, J:222308)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Foxn1 Mutation:	106 strains or lines available

References

Original:	J:192383 Harris BS, et al., Nude 2 Jackson: A new spontaneous mutation in Foxn1. MGI Direct Data Submission. 2013;
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24