Npc2<tm1e.1(EUCOMM)Wtsi> Targeted Allele Detail MGI Mouse (MGI:5513806)

Npc2^{tm1e.1(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

Symbol:	Npc2^{tm1e.1(EUCOMM)Wtsi}
Name:	NPC intracellular cholesterol transporter 2; targeted mutation 1e.1, Wellcome Trust Sanger Institute
MGI ID:	MGI:5513806
Gene:	Npc2 Location: Chr12:84801333-84819886 bp, - strand Genetic Position: Chr12, 39.37 cM
Alliance:	Npc2^{tm1e.1(EUCOMM)Wtsi} page
IMPC:	Npc2 gene page

Mutation
origin

Mutant Cell Line:	EPD0533_3_A06
Germline Transmission:	Earliest citation of germline transmission: J:200814
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-A^tm1Brd
Project Collection:	EUCOMM

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutation:		Insertion Vector: L1L2_Bact_P
		Mutation details: Cre excision of MGI:4451979 tm1e allele removes the promoter-driven neo leaving behind the lacZ reporter (J:200814)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Npc2 Mutation:	23 strains or lines available

References

Original:	J:200814 Toronto Centre for Phenogenomics, Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051). MGI Direct Data Submission. 2013;
All:	4 reference(s)

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