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Strit1 Gene Detail
Summary
  • Symbol
    Strit1
  • Name
    small transmembrane regulator of ion transport 1
  • Synonyms
    DWORF, Gm34302
  • Feature Type
    protein coding gene
  • IDs
    MGI:5593461
    NCBI Gene: 102637511
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr3:63388533-63391300 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5593461
 protein coding gene Chr3:63388516-63391327 (-)
129S1/SvImJ MGP_129S1SvImJ_G0006200
 lincRNA gene Chr3:62521741-62524509 (-)
A/J MGP_AJ_G0006192
 lincRNA gene Chr3:60651406-60654173 (-)
AKR/J MGP_AKRJ_G0006168
 lincRNA gene Chr3:61846888-61849655 (-)
BALB/cJ MGP_BALBcJ_G0006168
 lincRNA gene Chr3:60420722-60423489 (-)
C3H/HeJ MGP_C3HHeJ_G0006118
 lincRNA gene Chr3:62064362-62067129 (-)
C57BL/6NJ MGP_C57BL6NJ_G0006331
 lincRNA gene Chr3:64807366-64810133 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0005639
 lincRNA gene Chr3:57114877-57117671 (-)
CAST/EiJ MGP_CASTEiJ_G0006052
 lincRNA gene Chr3:62222658-62225424 (-)
CBA/J MGP_CBAJ_G0006103
 lincRNA gene Chr3:66895503-66898270 (-)
DBA/2J MGP_DBA2J_G0006122
 lincRNA gene Chr3:60064360-60067128 (-)
FVB/NJ MGP_FVBNJ_G0006146
 lincRNA gene Chr3:58873894-58876663 (-)
LP/J MGP_LPJ_G0006205
 lincRNA gene Chr3:63356303-63359071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0006136
 lincRNA gene Chr3:71391428-71394195 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0006335
 lincRNA gene Chr3:61777996-61780764 (-)
PWK/PhJ MGP_PWKPhJ_G0005997
 lincRNA gene Chr3:59655348-59658117 (-)
SPRET/EiJ MGP_SPRETEiJ_G0005906
 lincRNA gene Chr3:61284409-61292327 (-)
WSB/EiJ MGP_WSBEiJ_G0006099
 lincRNA gene Chr3:61908178-61910945 (-)



Homology
more
  • Human Ortholog
    STRIT1, small transmembrane regulator of ion transport 1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STRIT1, small transmembrane regulator of ion transport 1
  • Synonyms
    DWORF
  • Links
    NCBI Gene ID: 100507537
    UniProt: P0DN84

  • Chr Location
    chr3:155290227-155293683 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Transgenic
    1
  • Genomic Mutations
    2 involving Strit1
  • Find Mice (IMSR)
    0 strains or lines available
Mice homozygous for a knock-out allele exhibit impaired muscle relaxation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000103476 Ensembl Gene Model | MGI Sequence Detail 2768 C57BL/6J ±  kb
transcript ENSMUST00000192926 Ensembl | MGI Sequence Detail 243 Not Applicable  
polypeptide ENSMUSP00000147363 Ensembl | MGI Sequence Detail 34 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR044529 Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF
Other
Accession IDs
less
MGI:6283842
References
more
  • Summaries
    All 14
    Diseases 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:345725 Stege NM, et al., Deletion of DWORF does not affect cardiac function in aging and in PLN-R14del cardiomyopathy. Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H870-H876
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory