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Gene Expression Data
Assay Details
Assay
Reference: J:162095 Shiwaku H, et al., Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 2010 Jul 21;29(14):2446-60
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5638219
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: Anti-Sox2 (Y-17; sc-17320)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6A WT 1w: postnatal week 1 (more )
Note: Double labeled: green - Sox2; red - Calb1 (assay MGI:5638221).
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 6A WT Sox2 1w , 6A WT Merge 1w Expression was detected in Bergmann glia.
Specimen 6A Atx1-KI 1w: postnatal week 1; Atxn1tm1Hzo/Atxn1+ (more )
Note: Double labeled: green - Sox2; red - Calb1 (assay MGI:5638221).
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 6A Atx1-KI Sox2 1w , 6A Atx1-KI Merge 1w There was a decrease in Bergmann glia in the mutant.
Specimen 6A WT 16w: postnatal week 16 (more )
Note: Double labeled: green - Sox2; red - Calb1 (assay MGI:5638221).
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 6A WT Sox2 16w , 6A WT Merge 16w Expression was detected in Bergmann glia.
Specimen 6A Atx1-KI 16w: postnatal week 16; Atxn1tm1Hzo/Atxn1+ (more )
Note: Double labeled: green - Sox2; red - Calb1 (assay MGI:5638221).
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 6A Atx1-KI Sox2 16w , 6A Atx1-KI Merge 16w There was a decrease in Bergmann glia in the mutant.
Specimen 6A WT 40w: postnatal week 40 (more )
Note: Double labeled: green - Sox2; red - Calb1 (assay MGI:5638221).
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 6A WT Merge 40w , 6A WT Sox2 40w Expression was detected in Bergmann glia.
Specimen 6A Atx1-KI 40w: postnatal week 40; Atxn1tm1Hzo/Atxn1+ (more )
Note: Double labeled: green - Sox2; red - Calb1 (assay MGI:5638221).
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 6A Atx1-KI Sox2 40w , 6A Atx1-KI Merge 40w There was a decrease in Bergmann glia in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory