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Gene Expression Data
Assay Details
Assay
Reference: J:117269 Lavado A, et al., Prox1 expression patterns in the developing and adult murine brain. Dev Dyn. 2007 Feb;236(2):518-24
Assay type: RNA in situ
MGI Accession ID: MGI:5693787
Gene symbol: Prox1
Gene name: prospero homeobox 1
Probe: Prox1 homeobox probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 14.5 (more )
Note: coronal section
Structure Level Pattern Image Note
TS22: ganglionic eminence Present Widespread 1A Expression in the subventricular and mantle zones.
TS22: thalamus mantle layer Present 1A Expression in the dorsal thalamus.
TS22: amygdala Present Regionally restricted 1A Expression in the mantle zone.
TS22: hippocampus Present Regionally restricted 1A Expression in dentate gyrus neuroepithelium.

Specimen 1B: embryonic day 14.5 (more )
Note: coronal section
Structure Level Pattern Image Note
TS22: ganglionic eminence Present Widespread 1B Expression in the subventricular and mantle zones.
TS22: thalamus mantle layer Present 1B Expression in the dorsal thalamus.
TS22: thalamus subventricular zone Present Regionally restricted 1B Expression in the paraventricular nucleus.
TS22: hypothalamus subventricular zone Present Regionally restricted 1B Expression in the subventricular zone of the preoptic area.
TS22: amygdala Present Regionally restricted 1B Expression in the mantle zone.
TS22: hippocampus Present Regionally restricted 1B Expression in dentate gyrus neuroepithelium.

Specimen 1C: embryonic day 14.5 (more )
Note: coronal section
Structure Level Pattern Image Note
TS22: ganglionic eminence Present Widespread 1C Expression in the subventricular and mantle zones.
TS22: epithalamus mantle layer Present 1C
TS22: thalamus mantle layer Present Regionally restricted 1C Expression in the dorsal thalamus.
TS22: prethalamus Present Regionally restricted 1C Expression in the subventricular zone of the prethalamus; transcripts are surrounding the reticular nucleus and zona incerta.
TS22: zona incerta Present Regionally restricted 1C Expression in the subventricular zone of the prethalamus; transcripts are surrounding the reticular nucleus and zona incerta.
TS22: hippocampus Present Regionally restricted 1C Expression in dentate gyrus neuroepithelium.

Specimen 1D: embryonic day 14.5 (more )
Note: coronal section
Structure Level Pattern Image Note
TS22: epithalamus mantle layer Present 1D
TS22: prethalamus Present Regionally restricted 1D Expression in the subventricular zone of the prethalamus; transcripts are surrounding the reticular nucleus and zona incerta.
TS22: zona incerta Present Regionally restricted 1D Expression in the subventricular zone of the prethalamus; transcripts are surrounding the reticular nucleus and zona incerta.
TS22: hypothalamus subventricular zone Present Regionally restricted 1D Expression in the subventricular zone of the arcuate nucleus.
TS22: hippocampus Present Regionally restricted 1D Expression in dentate gyrus neuroepithelium.

Specimen 1E: embryonic day 14.5 (more )
Note: sagittal section
Structure Level Pattern Image Note
TS22: tectum Present Regionally restricted 1E Expression in the subventricular zone of the colliculus.
TS22: pretectum Present Widespread 1E Expression in the mantle zone (and subventricular zone).
TS22: midbrain tegmentum Present Regionally restricted 1E Expression in the subventricular zone.
TS22: pons Present Regionally restricted 1E Expression in the subventricular zone of the pontine neuroepithelium.
TS22: prethalamus Present Regionally restricted 1E Expression in the subventricular zone of the prethalamus.
TS22: hypothalamus subventricular zone Present Regionally restricted 1E Expression in the subventricular zone of the preoptic area and the arcuate nucleus.
TS22: thalamus mantle layer Present Regionally restricted 1E Expression in the dorsal thalamus.
TS22: hippocampus Present Regionally restricted 1E Expression in dentate gyrus neuroepithelium.

Specimen not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: medulla oblongata Present Regionally restricted Expression is present in the subventricular zone.
TS22: pons Present Regionally restricted Expression is present in the subventricular zone.

Specimen 3A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: tectum Present 3A Expression in the colliculus.
TS24: pretectum Present 3A
TS24: midbrain tegmentum Present 3A
TS24: prethalamus Present Regionally restricted 3A
TS24: epithalamus Present 3A
TS24: pons Present 3A

Specimen 3C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: thalamus Present 3C
TS24: prethalamus Present 3C
TS24: cerebral cortex subventricular zone Present 3C

Specimen 3E: embryonic day 16.5 (more )
Note: Double labeled: blue - Prox1 RNA; brown - Prox1 protein (assay MGI:5693875).
Structure Level Pattern Image Note
TS24: thalamus Present Regionally restricted 3E Areas of expression include the paraventricular nucleus.
TS24: prethalamus Present 3E
TS24: amygdala Present Regionally restricted 3E Expression is present in the subventricular zone.

Specimen 3F: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: thalamus Present 3F Areas of expression include the dorsal thalamus.
TS24: cerebral cortex subventricular zone Present 3F
TS24: hypothalamus Present Regionally restricted 3F Expression in the dorsomedial hypothalamus.

Specimen 3H: embryonic day 16.5 (more )
Note: Double labeled: blue - Prox1 RNA; brown - Prox1 protein (assay MGI:5693875).
Structure Level Pattern Image Note
TS24: amygdala Present Regionally restricted 3H Expression is present in the subventricular zone.
TS24: hypothalamus Present Regionally restricted 3H Expression is present in the ventromedial hypothalamus.
TS24: thalamus Present Regionally restricted 3H Areas of expression include the subgeniculate nucleus.
TS24: zona incerta Present Regionally restricted 3H Expression in the ventral portion.

Specimen 3J: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebellum external granule cell layer Present 3J

Specimen not shown: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: pons Present Areas of expression include the pontine nucleus.
TS24: neurohypophysis pars nervosa Present Expression in the posterior lobe of the pituitary.
TS24: hippocampus Present Areas of expression include the denate migratory stream.
TS24: medulla oblongata Present

Specimen 4A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: thalamus Strong Regionally restricted 4A Areas of expression include the laterodorsal and ventrolateral thalamus.
TS26: prethalamus Present 4A Expression in the area around the prethalamus.
TS26: dentate gyrus Present 4A

Specimen 4C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: thalamus Strong Regionally restricted 4C Areas of expression include the lateral dorsal thalamus, ventromedial thalamus, ventrolateral thalamus, and the subgeniculate nucleus.
TS26: zona incerta Present 4C
TS26: dentate gyrus Present 4C

Specimen 4E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: thalamus Strong Regionally restricted 4E Areas of expression include the posterior nucleus of thalamus.
TS26: dentate gyrus Present 4E

Specimen 4I: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebellum external granule cell layer Present 4I
TS26: tectum Present 4I Expression is present in the colliculus.
TS26: midbrain tegmentum Present 4I

Specimen 5A: postnatal day 15 (more )
Note: Double labeled: blue - Prox1; brown - Calb2 (assay MGI:5693764).
Structure Level Pattern Image Note
TS28: corpus callosum Present 5A Expression is present in neurons.

Specimen 5E: postnatal day 15 (more )
Note: Double labeled: blue - Prox1; brown - Calb2 (assay MGI:5693764).
Structure Level Pattern Image Note
TS28: anterior ventral thalamic nucleus Present 5E Expression in the anteroventral nucleus.
TS28: nucleus reuniens Present 5E

Specimen 5E inset: postnatal day 15 (more )
Note: Double labeled: blue - Prox1; brown - Calb2 (assay MGI:5693764).
Structure Level Pattern Image Note
TS28: nucleus reuniens Present 5E inset

Specimen 5F: postnatal day 15 (more )
Note: Double labeled: blue - Prox1; brown - Calb2 (assay MGI:5693764).
Structure Level Pattern Image Note
TS28: habenula Present 5F
TS28: anterior ventral thalamic nucleus Present 5F Expression in the anteroventral nucleus.
TS28: nucleus reuniens Present 5F

Specimen 5G: postnatal day 15 (more )
Note: Double labeled: blue - Prox1; brown - Calb2 (assay MGI:5693764).
Structure Level Pattern Image Note
TS28: paraventricular thalamic nucleus Present 5G

Specimen 5G upper inset: postnatal day 15 (more )
Note: Double labeled: blue - Prox1; brown - Calb2 (assay MGI:5693764).
Structure Level Pattern Image Note
TS28: dentate gyrus Present 5G upper inset
TS28: dentate gyrus subgranular zone Present 5G upper inset

Specimen 5G lower inset: postnatal day 15 (more )
Note: Double labeled: blue - Prox1; brown - Calb2 (assay MGI:5693764).
Structure Level Pattern Image Note
TS28: paraventricular thalamic nucleus Present 5G lower inset

Specimen not shown: postnatal (more )
Structure Level Pattern Image Note
TS28: dorsomedial hypothalamic nucleus Present
TS28: fimbria hippocampus Present
TS28: ventromedial hypothalamic nucleus Present


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory