Dpp4<tm1(DPP4)Vlcg> Targeted Allele Detail MGI Mouse (MGI:5788094)

Dpp4^{tm1(DPP4)Vlcg}
Targeted Allele Detail

Summary

Symbol:	Dpp4^{tm1(DPP4)Vlcg}
Name:	dipeptidylpeptidase 4; targeted mutation 1, Velocigene
MGI ID:	MGI:5788094
Gene:	Dpp4 Location: Chr2:62160417-62242575 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Alliance:	Dpp4^{tm1(DPP4)Vlcg} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:223728
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NTac)F1

Mutation
description

Allele Type:

Targeted (Inserted expressed sequence, Null/knockout)

Mutations:

Insertion, Intragenic deletion

Dpp4^{tm1(DPP4)Vlcg} expresses 1 gene

Mutation details: Exons 2 through 26, including the 3'UTR, of the human genomic sequence (from BAC RP11-68L22) replaced 79 kb of the corresponding mouse sequence. (J:223728)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:	73 strains or lines available

References

Original:	J:223728 Pascal KE, et al., Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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