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Gene Expression Data
Assay Details
Assay
Reference: J:106261 Kurohara K, et al., Essential roles of Meltrin beta (ADAM19) in heart development. Dev Biol. 2004 Mar 1;267(1):14-28
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6117016
Gene symbol: Adam19
Gene name: ADAM metallopeptidase domain 19
Results
Specimen 6A: embryonic day 11.5 (more )
Note: Triple labeled: red - Meltrin beta (Adam19); green - Itga4 (assay MGI:6117017); blue - DAPI.
Structure Level Pattern Image Note
TS19: outflow tract endocardial cushion Strong Regionally restricted 6A Strong expression in cushion mesenchyme, endocardial epithelial cells, and in mesenchymal cells delaminating from the epithelial layer.
Specimen 6B: embryonic day 11.5; Adam19tm1Asf/Adam19tm1Asf (more )
Note: Triple labeled: red - Meltrin beta (Adam19); green - Itga4 (assay MGI:6117017); blue - DAPI.
Structure Level Pattern Image Note
TS19: outflow tract endocardial cushion Absent 6B
Specimen 6C: embryonic day 11.5 (more )
Note: Triple labeled: red - Meltrin beta (Adam19); green - Itga4 (assay MGI:6117017); blue - DAPI.
Structure Level Pattern Image Note
TS19: atrioventricular endocardial cushion Strong Regionally restricted 6C Strong expression in cushion mesenchyme, endocardial epithelial cells, and in mesenchymal cells delaminating from the epithelial layer.
Specimen 6D: embryonic day 11.5; Adam19tm1Asf/Adam19tm1Asf (more )
Note: Triple labeled: red - Meltrin beta (Adam19); green - Itga4 (assay MGI:6117017); blue - DAPI.
Structure Level Pattern Image Note
TS19: atrioventricular endocardial cushion Absent 6D
Specimen 6E,6F,6G: embryonic day 11.5 (more )
Note: Triple labeled: red - Meltrin beta (Adam19); green - Pecam1 (assay MGI:6117018); blue - DAPI.
Structure Level Pattern Image Note
TS19: atrioventricular endocardial cushion Present Regionally restricted 6F , 6E , 6G Strong expression in mesenchyme. Weak expression in endocardial epithelial cells.
Specimen 6H,6I,6J: embryonic day 11.5; Adam19tm1Asf/Adam19tm1Asf (more )
Note: Triple labeled: red - Meltrin beta (Adam19); green - Pecam1 (assay MGI:6117018); blue - DAPI.
Structure Level Pattern Image Note
TS19: atrioventricular endocardial cushion Absent 6J , 6H , 6I
Specimen 7A: embryonic day 12.5 (more )
Note: Double labeled: red - Meltrin beta (Adam19); green - Pecam1 (assay MGI:6117018).
Structure Level Pattern Image Note
TS20: atrioventricular endocardial cushion Present Regionally restricted 7A Majority of expressing cells were mesenchymal.
Specimen 7B: embryonic day 12.5; Adam19tm1Asf/Adam19tm1Asf (more )
Note: Double labeled: red - Meltrin beta (Adam19); green - Pecam1 (assay MGI:6117018).
Structure Level Pattern Image Note
TS20: atrioventricular endocardial cushion Absent 7B
Specimen 7C: embryonic day 13.5 (more )
Note: Double labeled: red - Meltrin beta (Adam19); green - Pecam1 (assay MGI:6117018).
Structure Level Pattern Image Note
TS21: atrioventricular endocardial cushion Weak 7C Authors report decreased expression at E13.5
Specimen 7D: embryonic day 13.5; Adam19tm1Asf/Adam19tm1Asf (more )
Note: Double labeled: red - Meltrin beta (Adam19); green - Pecam1 (assay MGI:6117018).
Structure Level Pattern Image Note
TS21: atrioventricular endocardial cushion Absent 7D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory