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Gene Expression Data
Assay Details
Assay
Reference: J:136705 Jonckheere N, et al., Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15;318(2):224-35
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6386375
Gene symbol: Axin2
Gene name: axin 2
Reporter: lacZ
Direct Detection
Results
Specimen 6A: embryonic day 10.5; Axin2tm1Wbm/Axin2+ (more )
Note: Double labeled: blue - Axin2 reporter; brown - glucagon (Gcg; assay MGI:6386404).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 6A Expression predominantly in undifferentiated pancreatic epithelium and early differentiated (glucagon-expressing) cells. Scattered expression also detected in surrounding mesenchyme.
Specimen 6B: embryonic day 13.5; Axin2tm1Wbm/Axin2+ (more )
Note: Double labeled: blue - Axin2 reporter; brown - glucagon (Gcg; assay MGI:6386404).
Structure Level Pattern Image Note
TS21: pancreas mesenchyme Present Uniform 6B Uniform expression in mesenchymal cells.
TS21: pancreas epithelium Trace 6B Rare expression in pancreatic epithelial cells.
Specimen 6C: embryonic day 15.5; Axin2tm1Wbm/Axin2+ (more )
Note: Double labeled: blue - Axin2 reporter; brown - glucagon (Gcg; assay MGI:6386404).
Structure Level Pattern Image Note
TS23: pancreas mesenchyme Present 6C Predominant mesenchymal expression persists at E15.5.
TS23: pancreas epithelium Trace 6C Occasional expression in (glucagon-expressing) epitheial cells.
Specimen 6D: embryonic day 18.5; Axin2tm1Wbm/Axin2+ (more )
Note: Double labeled: blue - Axin2 reporter; brown - glucagon (Gcg; assay MGI:6386404).
Structure Level Pattern Image Note
TS26: pancreatic duct Present 6D Expression predominantly localized in pancreatic ducts.
TS26: endocrine pancreas Ambiguous Regionally restricted 6D Authors report expression largely absent from glucagon-expressing cells.
Specimen 6E: embryonic day 18.5; Axin2tm1Wbm/Axin2+ (more )
Note: Double labeled: blue - Axin2 reporter; brown - Ins1 (assay MGI:6386400) and Ins2 (assay MGI:6386401).
Structure Level Pattern Image Note
TS26: pancreatic duct Present 6E Expression predominantly localized in pancreatic ducts.
TS26: endocrine pancreas Ambiguous Regionally restricted 6E Authors report expression largely absent from glucagon-expressing cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/09/2024
MGI 6.24 		The Jackson Laboratory