Muc4<tm1Unc> Targeted Allele Detail MGI Mouse (MGI:6416171)

Muc4^tm1Unc
Targeted Allele Detail

Summary

Symbol:	Muc4^tm1Unc
Name:	mucin 4; targeted mutation 1, University of North Carolina
MGI ID:	MGI:6416171
Gene:	Muc4 Location: Chr16:32555089-32602786 bp, + strand Genetic Position: Chr16, 23.3 cM
Alliance:	Muc4^tm1Unc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:254258
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/SvEv

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: 981bp of genomic sequence containing the starting methionine in exon 1 was replaced with a reverse-oriented floxed MC1-neo cassette. (J:254258)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Muc4 Mutation:	238 strains or lines available

References

Original:	J:254258 Rowson-Hodel AR, et al., Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer. Oncogene. 2018 Jan 11;37(2):197-207
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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