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Gene Expression Data
Assay Details
Assay
Reference: J:265020 Tang X, et al., EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. J Clin Invest. 2017 Dec 1;127(12):4314-4325
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6456987
Gene symbol: Sftpb
Gene name: surfactant associated protein B
Results
Specimen 3A: embryonic day 18.5 (more )
Note: Double labeled: red - proSP-B (Sftpb); green - Abca3 (assay MGI:6456986).
Structure Level Pattern Image Note
TS26: lung Present 3A merge , 3A proSP-B
Specimen 3B: embryonic day 18.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Double labeled: red - proSP-B (Sftpb); green - Abca3 (assay MGI:6456986).
Structure Level Pattern Image Note
TS26: lung alveolus Strong Regionally restricted 3B proSP-B , 3B merge Expression accumulated in alveolar type 2 (AT2) cells. Abnormal expression in peripheral lung saccules.
Specimen 3E: embryonic day 18.5 (more )
Note: Triple labeled: green - proSP-B (Sftpbb); purple - proSP-C (Sftpc assay MGI:6456988); red - Lamp1 (assay MGI:6456990).
Structure Level Pattern Image Note
TS26: lung Present 3E
Specimen 3F: embryonic day 18.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Triple labeled: green - proSP-B (Sftpbb); purple - proSP-C (Sftpc assay MGI:6456988); red - Lamp1 (assay MGI:6456990).
Structure Level Pattern Image Note
TS26: lung alveolus Strong Regionally restricted 3F Expression colocalized with LAMP-1 in alveolar type 2 (AT2) cells, indicating retention of unprocessed precursors.
Specimen S2C: embryonic day 18.5 (more )
Note: Double labeled: green - proSP-B (Sftpbb); red - Ager (assay MGI:6456992).
Structure Level Pattern Image Note
TS26: lung Present S2C merge , S2C proSP-B
Specimen S2D: embryonic day 18.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Double labeled: green - proSP-B (Sftpbb); red - Ager (assay MGI:6456992).
Structure Level Pattern Image Note
TS26: lung Present S2D merge , S2D pro-SP-B
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
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