Gene Expression Data
Assay Details
Assay
|
Reference:
|
J:333013
Huang T, et al., Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects. Gastroenterology. 2022 Jan;162(1):179-192.e11
|
Assay type:
|
Immunohistochemistry
|
MGI Accession ID:
|
MGI:7434129
|
Gene symbol:
|
Sox10
|
Gene name:
|
SRY (sex determining region Y)-box 10
|
|
Results
|
Specimen
S2A +/+:
embryonic day 9.5
(more )
Specimen
S2A +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 9.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS15: migrating neural crest |
migratory neural crest cell |
Present |
Regionally restricted |
S2Ai
|
Expression in sacral neural crest cells emigrating from dorsal neural tube adjacent to somite 25.
|
Specimen
S2A Dom/+:
embryonic day 9.5; Sox10Dom/Sox10 +
(more )
Specimen
S2A Dom/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10+
|
Age:
|
embryonic day 9.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS15: migrating neural crest |
migratory neural crest cell |
Weak |
Regionally restricted |
S2Aii
|
Expression in fewer sacral neural crest cells emigrating from neural tube caudal to somite 24 than in wildtype.
|
Specimen
S2A Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 9.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS15: migrating neural crest |
migratory neural crest cell |
Present |
Regionally restricted |
S2Aiii
|
Expression in fewer sacral neural crest cells emigrating from neural tube caudal to somite 24 than in wildtype.
|
Specimen
1A +/+:
embryonic day 10.5
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
1A +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS17: migrating neural crest |
migratory neural crest cell |
Present |
Regionally restricted |
1Ai
|
Expression in sacral neural crest cells along medial pathway and their pioneer (most ventrally located) cells.
|
Specimen
1A Dom/+:
embryonic day 10.5; Sox10Dom/Sox10 +
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
1A Dom/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10+
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS17: migrating neural crest |
migratory neural crest cell |
Weak |
Regionally restricted |
1Aii
|
Significant reduction in expressing pioneer sacral neural crest cells in periaortic area compared to wildtype.
|
Specimen
1A Dom/Dom:
embryonic day 10.5; Sox10Dom/ Sox10Dom
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
1A Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS17: migrating neural crest |
migratory neural crest cell |
Weak |
Regionally restricted |
1Aiii
|
Significant reduction in expressing pioneer sacral neural crest cells in periaortic area compared to wildtype.
|
Specimen
1D +/+:
embryonic day 11.5
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
1D +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS19: pelvic ganglion |
migratory neural crest cell |
Present |
Regionally restricted |
1Di
|
Expression in sacral neural crest cells - pioneer cells aggregated as pelvic ganglia lateral to distal hindgut.
|
Specimen
1D Dom/+:
embryonic day 11.5; Sox10Dom/Sox10 +
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
1D Dom/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10+
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS19: pelvic ganglion |
migratory neural crest cell |
Ambiguous |
|
1Dii
|
Expressing cells in pelvic ganglion significantly reduced in number.
|
Specimen
1D Dom/Dom:
embryonic day 11.5; Sox10Dom/ Sox10Dom
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
1D Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: pelvic ganglion |
Absent |
|
1Diii
|
Neural crest cells not found in position of pelvic ganglion.
|
Specimen
S2C +/+:
embryonic day 12.5
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
S2C +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
optical section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS20: pelvic ganglion |
migratory neural crest cell |
Present |
Regionally restricted |
S2Ci
|
Expression in sacral neural crest cells.
|
Specimen
S2C Dom/+:
embryonic day 12.5; Sox10Dom/Sox10 +
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
S2C Dom/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10+
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
optical section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS20: pelvic ganglion |
migratory neural crest cell |
Weak |
Regionally restricted |
S2Cii
|
Signficantly fewer sacral neural crest cells than in wildtype.
|
Specimen
S2C Dom/Dom:
embryonic day 12.5; Sox10Dom/ Sox10Dom
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
S2C Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
optical section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Specimen
S2E +/+:
embryonic day 13.5
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
S2E +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 13.5
|
Sex:
|
Not Specified
|
Type:
|
optical section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS21: pelvic ganglion |
migratory neural crest cell |
Present |
Regionally restricted |
S2Ei
|
Expression in sacral neural crest cells.
|
Specimen
S2E Dom/+:
embryonic day 13.5; Sox10Dom/Sox10 +
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
S2E Dom/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10+
|
Age:
|
embryonic day 13.5
|
Sex:
|
Not Specified
|
Type:
|
optical section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS21: pelvic ganglion |
migratory neural crest cell |
Weak |
Regionally restricted |
S2Eii
|
Signficantly fewer sacral neural crest cells than in wildtype.
|
Specimen
S2E Dom/Dom:
embryonic day 13.5; Sox10Dom/ Sox10Dom
(more )
Note: Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
Specimen
S2E Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 13.5
|
Sex:
|
Not Specified
|
Type:
|
optical section
|
Note:
|
Double labeled: green - Sox10; red - p75 (Ngfr assay MGI:7434130).
|
Specimen
S2G +/+:
embryonic day 14.5
(more )
Note: Double labeled: green - Sox10; red - PGP9.5 (Uchl1 assay MGI:7434131).
Specimen
S2G +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Note:
|
Double labeled: green - Sox10; red - PGP9.5 (Uchl1 assay MGI:7434131).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS22: hindgut |
neural crest cell |
Present |
Regionally restricted |
S2Gii
,
S2Giii
,
S2Gi
|
Expression in neural crest cells in middle and distal regions of hindgut segments.
|
TS22: pelvic ganglion |
migratory neural crest cell |
Present |
Regionally restricted |
S2Giii
,
S2Gi
|
Expression in sacral neural crest cells.
|
Specimen
S2G Dom/+:
embryonic day 14.5; Sox10Dom/Sox10 +
(more )
Note: Double labeled: green - Sox10; red - PGP9.5 (Uchl1 assay MGI:7434131).
Specimen
S2G Dom/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10+
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Note:
|
Double labeled: green - Sox10; red - PGP9.5 (Uchl1 assay MGI:7434131).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS22: hindgut |
neural crest cell |
Present |
Regionally restricted |
S2Gvi
,
S2Gv
,
S2Giv
|
Expression in neural crest cells in middle and distal regions of hindgut segments.
|
TS22: pelvic ganglion |
migratory neural crest cell |
Weak |
Regionally restricted |
S2Gvi
,
S2Giv
|
Signficantly fewer sacral neural crest cells in pelvic ganglia than in wildtype.
|
Specimen
S2G Dom/Dom:
embryonic day 14.5; Sox10Dom/ Sox10Dom
(more )
Note: Double labeled: green - Sox10; red - PGP9.5 (Uchl1 assay MGI:7434131).
Specimen
S2G Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Note:
|
Double labeled: green - Sox10; red - PGP9.5 (Uchl1 assay MGI:7434131).
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS22: hindgut |
neural crest cell |
Present |
Regionally restricted |
S2Gviii
,
S2Gvii
,
S2Gix
|
Expression in neural crest cells in middle and distal regions of hindgut segments.
|
TS22: pelvic ganglion |
migratory neural crest cell |
Absent |
|
S2Gvii
,
S2Gix
|
Signficantly fewer sacral neural crest cells in pelvic ganglia than in wildtype.
|
Specimen
S3A Sacral level +/+:
embryonic day 10.5
(more )
Note: Double labeled: red - Sox10; green - BrdU.
Specimen
S3A Sacral level +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: red - Sox10; green - BrdU.
|
Specimen
S3A Sacral level Dom/Dom:
embryonic day 10.5; Sox10Dom/ Sox10Dom
(more )
Note: Double labeled: red - Sox10; green - BrdU.
Specimen
S3A Sacral level Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: red - Sox10; green - BrdU.
|
Specimen
S3C Sacral level +/+:
embryonic day 10.5
(more )
Note: Double labeled: red - Sox10; green - TUNEL.
Specimen
S3C Sacral level +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: red - Sox10; green - TUNEL.
|
Specimen
S3C Sacral level Dom/Dom:
embryonic day 10.5; Sox10Dom/ Sox10Dom
(more )
Note: Double labeled: red - Sox10; green - TUNEL.
Specimen
S3C Sacral level Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: red - Sox10; green - TUNEL.
|
Specimen
S3E +/+:
embryonic day 10.5
(more )
Note: Double labeled: red - Sox10; green - Mki67 (assay MGI:7434132).
Specimen
S3E +/+:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: red - Sox10; green - Mki67 (assay MGI:7434132).
|
Specimen
S3E Dom/Dom:
embryonic day 10.5; Sox10Dom/ Sox10Dom
(more )
Note: Double labeled: red - Sox10; green - Mki67 (assay MGI:7434132).
Specimen
S3E Dom/Dom:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6J
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Note:
|
Double labeled: red - Sox10; green - Mki67 (assay MGI:7434132).
|
|