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Gene Expression Data
Assay Details
Assay
Reference: J:324832 Sun Y, et al., Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages. Cell Rep. 2022 Mar 22;38(12):110542
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7489979
Gene symbol: Shox2
Gene name: SHOX homeobox 2
Reporter: other (see notes)
Antibody: anti-V5-Tag (MCA1360)
Detection system: Secondary antibody
Assay notes: The expression reporter was a V5 tag fused to the Shox2 gene.
Results
Specimen S8G/H: embryonic day 9.5; Shox2em1(icre)Zyliu/Shox2+ (more )
Note: Triple labeled: green - Shox2 reporter; red - Neurod1 (assay MGI:7493524); blue - Hoechst.
Structure Level Pattern Image Note
TS16: cranial ganglion Present Regionally restricted S8G' , S8H' , S8H'' , S8G'' Expression is seen in cells committed to be cochleo-vestibular and geniculate ganglion cells.
TS16: otocyst epithelium Absent S8G' , S8G''
Specimen S8I: embryonic day 13.5; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Shox2em1(icre)Zyliu/Shox2+ (more )
Note: Conditional mutant. Multi-labeled: green - Shox2 reporter; white - Myo7a (assay MGI:7493893); red - Cre reporter; blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS22: cochlear ganglion neuron Present S8I''' , S8J''' , S8J , S8I Expression is considerably higher in spiral ganglion neurons (SGNs) than vestibular ganglion neurons (VGNs).
TS22: vestibular ganglion neuron Weak S8K''' , S8I''' , S8K , S8I Expression is considerably higher in spiral ganglion neurons (SGNs) than vestibular ganglion neurons (VGNs).
Specimen S8N: postnatal day 42; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Shox2em1(icre)Zyliu/Shox2+ (more )
Note: Conditional mutant. Multi-labeled: white - Shox2 reporter; green - Map2 (assay MGI:7493890); red - Cre reporter; blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: cochlear ganglion spiral ganglion neuron Present S8N'' , S8N''' Expression is considerably higher in spiral ganglion neurons than vestibular ones.
Specimen S8O: postnatal day 42; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Shox2em1(icre)Zyliu/Shox2+ (more )
Note: Conditional mutant. Multi-labeled: white - Shox2 reporter; green - Map2 (assay MGI:7493890); red - Cre reporter; blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: vestibular ganglion neuron Present S8O'' , S8O''' Expression is considerably higher in spiral ganglion neurons than vestibular ones.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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