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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7507060
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: Anti-Ki-67 (Clone B56)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 8C: postnatal day 6; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: green - Mki67; red - Patj (assay MGI:7507063).
Structure Level Pattern Image Note
TS28: retina Present Regionally restricted 8C Expression was detected in mitotic cells.
Specimen 8D: postnatal day 6; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: green - Mki67; red - Patj (assay MGI:7507063).
Structure Level Pattern Image Note
TS28: retina Present Regionally restricted 8D Misplaced immunopositive mitotic cells were detected. A subset of immunopositive cells were co-stained with Patj at the periphery of the developing retina.
Specimen not shown Control: postnatal day 3; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS27: retina Present Regionally restricted Expression was detected in mitotic cells. Data was presented in a histogram in Fig. 8B.
Specimen not shown cKO: postnatal day 3; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: retina Present Regionally restricted The histogram in Fig. 8B indicated an increase in immunopositive mitotic cells in the retina of the Crb2Chx10 cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
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