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Gene Expression Data
Assay Details
Assay
Reference: J:333559 Rupani DN, et al., Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling. Development. 2023 Jan 15;150(2):dev201097
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539127
Gene symbol: Krt19
Gene name: keratin 19
Antibody: anti-keratin 19 (TROMA-III)
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 2B Control: postnatal day 21; Adartm1Knk/?, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1a+/? (more )
Note: Multi-labeled: green - Krt19; red - Amy (assay MGI:7539125); white - Cga (assay MGI:7539126); blue - hematoxylin. Control is either non-Cre-expressing OR Adar1 heterozygous litter mate.
Structure Cell Type Level Pattern Image Note
TS28: pancreatic duct pancreatic ductal cell Present 2B Control , 2B Control inset
Specimen 2B CYA: postnatal day 21; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Multi-labeled: green - Krt19; red - Amy (assay MGI:7539125); white - Cga (assay MGI:7539126); blue - hematoxylin.
Structure Cell Type Level Pattern Image Note
TS28: pancreatic acinus pancreatic ductal cell Strong Regionally restricted 2B CYA Authors report an increased in ductal cell area.
Specimen 2J Control: postnatal day 21; Adartm1Knk/?, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1a+/? (more )
Note: Multi-labeled: white - Krt19; red - Amy (assay MGI:7539125); green - Sox9 (assay MGI:7539129); blue - hematoxylin. Control is either non-Cre-expressing OR Adar1 heterozygous litter mate.
Structure Cell Type Level Pattern Image Note
TS28: pancreatic acinus pancreatic ductal cell Present 2J Control inset , 2J Control
Specimen 2J CYA: postnatal day 21; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Multi-labeled: white - Krt19; red - Amy (assay MGI:7539125); green - Sox9 (assay MGI:7539129); blue - hematoxylin.
Structure Level Pattern Image Note
TS28: pancreas Present Regionally restricted 2J CYA , 2J CYA inset Increased number of cells co-expressing Amy and Krt19.
Specimen 4G Control: postnatal month 6; Adartm1Knk/Adar+, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Mavstm1Zjc/Mavstm1Zjc, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Multi-labeled: green - Krt19; red - Amy (assay MGI:7539125); white - Cga (assay MGI:7539126); blue - hematoxylin. Control is either non-Cre-expressing OR Adar1 heterozygous litter mate.
Structure Cell Type Level Pattern Image Note
TS28: pancreatic duct pancreatic ductal cell Present 4G Control , 4G Control inset
Specimen 4G CYAM: postnatal month 6; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Mavstm1Zjc/Mavstm1Zjc, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Multi-labeled: green - Krt19; red - Amy (assay MGI:7539125); white - Cga (assay MGI:7539126); blue - hematoxylin.
Structure Cell Type Level Pattern Image Note
TS28: pancreatic duct pancreatic ductal cell Present 4G CYAM , 4G CYAM inset No significant difference in ductal cells compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/22/2024
MGI 6.24 		The Jackson Laboratory