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Gene Expression Data
Assay Details
Assay
Reference: J:333559 Rupani DN, et al., Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling. Development. 2023 Jan 15;150(2):dev201097
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539128
Gene symbol: Epcam
Gene name: epithelial cell adhesion molecule
Antibody: G8.8
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 2D Control: embryonic day 18.5; Adartm1Knk/?, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1a+/? (more )
Note: Triple labeled: yellow - Epcam; green - Amy (assay MGI:7539125); blue - DAPI. Control is either non-Cre-expressing OR Adar1 heterozygous litter mate.
Structure Level Pattern Image Note
TS26: pancreatic acinus Present 2D Control , 2D Control inset
Specimen 2D CYA: embryonic day 18.5; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Triple labeled: yellow - Epcam; green - Amy (assay MGI:7539125); blue - DAPI.
Structure Level Pattern Image Note
TS26: pancreatic acinus Present Regionally restricted 2D CYA , 2D CYA inset Authors report increase in acinar lumen length.
Specimen 2E Control: postnatal day 2; Adartm1Knk/?, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1a+/? (more )
Note: Triple labeled: yellow - Epcam; green - Amy (assay MGI:7539125); blue - DAPI. Control is either non-Cre-expressing OR Adar1 heterozygous litter mate.
Structure Level Pattern Image Note
TS27: pancreatic acinus Present 2E Control , 2E Control inset
Specimen 2E CYA: postnatal day 2; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Triple labeled: yellow - Epcam; green - Amy (assay MGI:7539125); blue - DAPI.
Structure Level Pattern Image Note
TS27: pancreatic acinus Present Regionally restricted 2E CYA , 2E CYA inset Authors report small cytoplasmic area in acinar clusters at P2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/22/2024
MGI 6.24 		The Jackson Laboratory