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Gene Expression Data
Assay Details
Assay
Reference: J:129202 Dunty WC Jr, et al., Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development. 2008 Jan;135(1):85-94
Assay type: RNA in situ
MGI Accession ID: MGI:7574751
Gene symbol: Mesp2
Gene name: mesoderm posterior 2
Probe: MesP2 cDNA2
Probe preparation: Antisense RNA
Results
Specimen 3K/O: embryonic day 8.5 (more )
Note: 10 somites. Double labeled: purple - Mesp2; orange - Uncx (assay MGI:7574674).
Structure Level Pattern Image Note
TS13: unsegmented mesenchyme Present Regionally restricted 3K , 3O Expressed at the anterior border.
Specimen 3L/P: embryonic day 8.5; Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 10 somites. Double labeled: purple - Mesp2; orange - Uncx (assay MGI:7574674).
Structure Level Pattern Image Note
TS13: unsegmented mesenchyme Absent 3L , 3P
Specimen 3M/Q: embryonic day 8.5; Ctnnb1tm1Mmt/Ctnnb1+, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 10 somites. Double labeled: purple - Mesp2; orange - Uncx (assay MGI:7574674).
Structure Level Pattern Image Note
TS13: unsegmented mesenchyme Present 3Q , 3M
Specimen 3N/R: embryonic day 8.5; Ctnnb1tm1Mmt/Ctnnb1+, Tg(T-cre)1Lwd/0, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: Conditional mutant. 10 somites. Double labeled: purple - Mesp2; orange - Uncx (assay MGI:7574674).
Structure Level Pattern Image Note
TS13: unsegmented mesenchyme Present 3N , 3R Expression was rescued.
Specimen 3S: embryonic day 8.0 (more )
Note: 2-5 somites.
Structure Level Pattern Image Note
TS12: unsegmented mesenchyme Present Regionally restricted 3S Expressed at the anterior border, adjacent to the anterior end of the node.
Specimen 3T: embryonic day 8.0; Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 2-5 somites.
Structure Level Pattern Image Note
TS12: unsegmented mesenchyme Present Regionally restricted 3T Expression was posteriorized in Wnt3a-/- mutants, abutting the posterior-most end of the node.
Specimen 3U: embryonic day 8.0; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 2-5 somites.
Structure Level Pattern Image Note
TS12: unsegmented mesenchyme Absent 3U Expression was generally absent (5/6 embryos).
Specimen 3V: embryonic day 8.0; Ctnnb1tm1Mmt/Ctnnb1+, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 2-5 somites.
Structure Level Pattern Image Note
TS12: unsegmented mesenchyme Present Regionally restricted 3V Multiple anteriorized stripes of expression were observed in the expanded presomitic mesenchyme.
Specimen not shown: embryonic day 8.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 10 somites.
Structure Level Pattern Image Note
TS13: unsegmented mesenchyme Absent
Specimen not shown: embryonic day 8.2; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 0-4 somites.
Structure Level Pattern Image Note
TS12: unsegmented mesenchyme Present Regionally restricted In this one LOF embryo, stripe was undefined and further posteriorized than in Wnt3a-/- embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory