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Gene Expression Data
Assay Details
Assay
Reference: J:346442 Migale R, et al., FOXL2 interaction with different binding partners regulates the dynamics of ovarian development. Sci Adv. 2024 Mar 22;10(12):eadl0788
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7628315
Gene symbol: Sox9
Gene name: SRY (sex determining region Y)-box 9
Antibody: Anti-Sox9 (AB5535)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen S8 8 weeks XY: postnatal week 8; Foxl2em1Rlb/Foxl2+ (more )
Note: Double labeled: red - Sox9; green - Foxl2 reporter (assay MGI:7628309).
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Present S8_8W XY EGFP/+ GFP-SOX9 , S8_8W XY EGFP/+ SOX9
Specimen S16A Control: postnatal day 0; Usp7tm2Wgu/Usp7tm2Wgu (more )
Note: Double labeled: red - Sox9; green - Ddx4 (assay MGI:7628313).
Structure Cell Type Level Pattern Image Note
TS27: Sertoli cell Sertoli cell Present S16A Control (lower)
Specimen S16A Sf1:Cretg/+;Usp7fl/fl: postnatal day 0; Tg(Nr5a1-cre)2Klp/0, Usp7tm2Wgu/Usp7tm2Wgu (more )
Note: Conditional mutant. Double labeled: red - Sox9; green - Ddx4 (assay MGI:7628313).
Structure Cell Type Level Pattern Image Note
TS27: Sertoli cell Sertoli cell Present S16A Sf1:Cretg/+;Usp7fl/fl (lower) Abnormal distribution of Sertoli cells.
Specimen S16B Control: postnatal day 7; Usp7tm2Wgu/Usp7tm2Wgu (more )
Note: Double labeled: red - Sox9; green - Ddx4 (assay MGI:7628313).
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Present S16B Control DDX4/SOX9 , S16B Control SOX9
Specimen S16B Sf1:Cretg/+;Usp7fl/fl: postnatal day 7; Tg(Nr5a1-cre)2Klp/0, Usp7tm2Wgu/Usp7tm2Wgu (more )
Note: Conditional mutant. Double labeled: red - Sox9; green - Ddx4 (assay MGI:7628313).
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Present S16B Sf1:Cretg/+;Usp7fl/fl DDX4/SOX9 , S16B Sf1:Cretg/+;Usp7fl/fl SOX9 Abnormal distribution of Sertoli cells.
TS28: testis epithelium Absent S16B Sf1:Cretg/+;Usp7fl/fl SOX9 , S16B Sf1:Cretg/+;Usp7fl/fl DDX4/SOX9 Authors report a fluid-filled cavity lined by a Sox9-negative epithelium.
Specimen S16D Control: postnatal week 8; Usp7tm2Wgu/Usp7tm2Wgu (more )
Note: Double labeled: red - Sox9; green - Ddx4 (assay MGI:7628313).
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Present S16D Control (lower) , S16D Control (upper)
Specimen S16D Sf1:Cretg/+;Usp7fl/fl: postnatal week 8; Tg(Nr5a1-cre)2Klp/0, Usp7tm2Wgu/Usp7tm2Wgu (more )
Note: Conditional mutant. Double labeled: red - Sox9; green - Ddx4 (assay MGI:7628313).
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Present S16D Sf1:Cretg/+;Usp7fl/fl (lower) , S16D Sf1:Cretg/+;Usp7fl/fl (upper) Reduction in number of Sertoli cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory