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Gene Expression Data
Assay Details
Assay
Reference: J:312371 Da Silva F, et al., Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J. 2021 Oct 1;40(19):e108041
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643166
Gene symbol: Eomes
Gene name: eomesodermin
Antibody: anti-Eomes (Dan11mag, 50-4875-82,14-4875-80)
Detection system: Secondary antibody coupled to Alexa Fluor 647
Results
Specimen 1B Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 1B Co
Specimen 1B DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 1B DKO The proportion of neocortical wall thickness constituted by the ventricular zone was increased by 12%, whereas that constituted by the subventricular zone and intermediate zone+cortical plate was decreased by 20% and 18%, respectively, compared with the control.
Specimen 1F Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 1F Co Expressed in basal progenitors.
Specimen 1F DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 1F DKO Expression in the basal progenitors was decreased (-38%) compared with the control.
Specimen 1Ka: embryonic day 12.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: red - Eomes; green - Ccny (assay MGI:7643169).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex subventricular zone neural progenitor cell Present 1Ka Expressed in basal progenitors.
Specimen 1Kb: embryonic day 12.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: red - Eomes; green - Ccnyl1 (assay MGI:7643170).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex subventricular zone neural progenitor cell Present 1Kb Expressed in basal progenitors.
Specimen 1Kc: embryonic day 12.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: red - Eomes; green - Lrp6 (assay MGI:7643171).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex subventricular zone neural progenitor cell Present 1Kc Expressed in basal progenitors.
Specimen 2D Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: red - Eomes; green - BrdU.
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 2D Co Expressed in basal progenitors.
Specimen 2D DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Note: Double labeled: red - Eomes; green - BrdU.
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 2D DKO The proportion of basal progenitors (Tbr2+) that were in S-phase (BrdU+) was moderately decreased, compared to control (quantified in Fig 2E).
Specimen 5K Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: red - Eomes; green - Sox11 (assay MGI:7643222).
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 5K Co Tbr2 , 5K Co merge Expressed in basal progenitors.
Specimen 5K DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Note: Double labeled: red - Eomes; green - Sox11 (assay MGI:7643222).
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 5K DKO merge , 5K DKO Tbr2 Expressed in basal progenitors.
Specimen not shown Co: embryonic day 11.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Structure Cell Type Level Pattern Image Note
TS19: telencephalon neural progenitor cell Present Expressed in basal progenitors.
Specimen not shown DKO: embryonic day 11.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Structure Cell Type Level Pattern Image Note
TS19: telencephalon neural progenitor cell Present The proportion of basal progenitors (Tbr2+) that were in S-phase (BrdU+) was moderately decreased, compared to control (quantified in Fig 2E).
Specimen not shown Co: embryonic day 12.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex subventricular zone neural progenitor cell Present Expressed in basal progenitors.
Specimen not shown DKO: embryonic day 12.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex subventricular zone neural progenitor cell Present The proportion of basal progenitors (Tbr2+) that were in S-phase (BrdU+) was moderately decreased, compared to control (quantified in Fig 2E).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory