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Gene Expression Data
Assay Details
Assay
Reference: J:312371 Da Silva F, et al., Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J. 2021 Oct 1;40(19):e108041
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643171
Gene symbol: Lrp6
Gene name: low density lipoprotein receptor-related protein 6
Antibody: anti-Phospho-LRP6 (T1479)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1Jc: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted 1Jc Concentrated at the apical cell cortex/apical plasma membrane, in 91% of mitotic apical progenitors analyzed.
Specimen 1Kc: embryonic day 12.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: green - Lrp6; red - Eomes (assay MGI:7643166).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex subventricular zone neural progenitor cell Present 1Kc Observed in 48% of mitotic basal progenitors.
Specimen 1L Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 1L Co
TS21: cerebral cortex ventricular layer neural progenitor cell Present 1L Co
Specimen 1L DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 1L DKO Decrease (-15%) expression, compared with the control (quantified in the Fig 1M).
TS21: cerebral cortex ventricular layer neural progenitor cell Present 1L DKO Decrease (-15%) expression, compared with the control (quantified in the Fig 1M).
Specimen Ev1 K Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted EV1_K LRP6 The greatest concentration of immunoreactivity at the apical cell cortex/apical plasma membrane.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/07/2025
MGI 6.24 		The Jackson Laboratory