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Gene Expression Data
Assay Details
Assay
Reference: J:312371 Da Silva F, et al., Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J. 2021 Oct 1;40(19):e108041
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643222
Gene symbol: Sox11
Gene name: SRY (sex determining region Y)-box 11
Antibody: anti-Sox11
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5H Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: green - Sox11; red - pHH3.
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 5H Co Sox11 , 5H Co merge
Specimen 5H DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Note: Double labeled: green - Sox11; red - pHH3.
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 5H DKO merge , 5H DKO Sox11 Significantly decreased expression (-23%) in mitotic cells, compared with the control (quantified in Fig 5I).
Specimen 5K Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: green - Sox11; red - Eomes (assay MGI:7643166).
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 5K Co Sox11 , 5K Co merge Coexpressed with Tbr2/Eomes in basal progenitors.
Specimen 5K DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Note: Double labeled: green - Sox11; red - Eomes (assay MGI:7643166).
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present 5K DKO Sox11 , 5K DKO merge Decreased expression (-10%) in basal progenitors, compared with the control (quantified in Fig 5L).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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