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Gene Expression Data
Assay Details
Assay
Reference: J:339076 Meng H, et al., Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation. Front Cell Dev Biol. 2023;11:1229788
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643479
Gene symbol: Mlkl
Gene name: mixed lineage kinase domain-like
Antibody: Anti-MLKL (phospho S345) antibody [EPR9515(2)] (ab196436)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 1E left: embryonic day 10.5 (more )
Note: Double labeled: magenta - Mlkl; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS17: telencephalon Present Regionally restricted 1E left Expressed mainly at the surface or the interface between cortex and ventricle. Approximately, 45.5% co-expressed with CD31/Pecam1.
Specimen 1E right: embryonic day 10.5 (more )
Note: Double labeled: magenta - Mlkl; green - Sox18 (assay MGI:7643481).
Structure Level Pattern Image Note
TS17: telencephalon Present Regionally restricted 1E right Expressed mainly at the surface or the interface between cortex and ventricle. Approximately, 31.4% co-expressed with Sox18.
Specimen 1G left: postnatal day 1 (more )
Note: Double labeled: magenta - Mlkl; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS27: epidermis Present 1G left Positive cells distributed mainly in epidermal layer. Approximately 22-23% co-expressed CD31/Pecam1.
Specimen 1G right: postnatal day 1 (more )
Note: Double labeled: magenta - Mlkl; green - Sox18 (assay MGI:7643481).
Structure Level Pattern Image Note
TS27: epidermis Present 1G right Positive cells distributed mainly in epidermal layer. Approximately 22-23% co-expressed Sox18.
Specimen S2A: embryonic day 10.5 (more )
Note: Double labeled: magenta - Mlkl; green - Pdgfrb (assay MGI:7643487).
Structure Cell Type Level Pattern Image Note
TS17: telencephalon Present Regionally restricted S2A Expressed mainly at the surface or the interface between cortex and ventricle.
TS17: telencephalon brain pericyte Absent S2A No co-expression with Pdgfrb.
Specimen S2B: postnatal day 1 (more )
Note: Double labeled: magenta - Mlkl; green - Pdgfrb (assay MGI:7643487).
Structure Cell Type Level Pattern Image Note
TS27: epidermis Present S2B Positive cells distributed mainly in epidermal layer.
TS27: epidermis pericyte Absent S2B No co-expression with Pdgfrb.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/09/2024
MGI 6.24 		The Jackson Laboratory