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Gene Expression Data
Assay Details
Assay
Reference: J:339076 Meng H, et al., Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation. Front Cell Dev Biol. 2023;11:1229788
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643483
Gene symbol: Sox18
Gene name: SRY (sex determining region Y)-box 18
Antibody: Sox-18 Antibody (D-8): sc-166025
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 3C WT: postnatal day 7 (more )
Note: Double labeled: magenta - Sox18; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS28: cerebral cortex Present 3C WT Expressed in venous-lymphatic endothelial cells localized at the upper layers.
Specimen 3C KO: postnatal day 7; Mlklem1Jhan/Mlklem1Jhan (more )
Note: Double labeled: magenta - Sox18; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS28: cerebral cortex Present 3C KO Exhibited a deeper distribution from the surface, and the percentages of Pecam1+/Sox18+ cells increased significantly, compared with the wild-type.
Specimen 4C WT: postnatal day 7 (more )
Note: Double labeled: magenta - Sox18; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS28: epidermis Present 4C WT Positive cells localized mainly in the epidermal layer.
Specimen 4C KO: postnatal day 7; Mlklem1Jhan/Mlklem1Jhan (more )
Note: Double labeled: magenta - Sox18; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS28: skin Present 4C KO Positive cells expanded beyond epidermal layer and even into mesenchyme layers.
TS28: epidermis Present 4C KO More positive cells compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/09/2024
MGI 6.24 		The Jackson Laboratory