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Gene Expression Data
Assay Details
Assay
Reference: J:321836 Zhao K, et al., LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development. Development. 2022 Mar 15;149(6):dev200458
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7711947
Gene symbol: H2ax
Gene name: H2A.X variant histone
Antibody: anti-gamma H2A.X (phospho S139) (abcam; ab11174)
Detection system: Secondary antibody
Results
Specimen 3K Ctrl RV: embryonic day 11.5 (more )
Note: Double labeled: green - H2ax; red - Tnnt2 (assay MGI:7711946).
Structure Cell Type Level Pattern Image Note
TS19: right ventricle cardiac muscle fetal cardiomyocyte Present 3K Ctrl RV
Specimen 3K Ctrl LV: embryonic day 11.5 (more )
Note: Double labeled: green - H2ax; red - Tnnt2 (assay MGI:7711946).
Structure Cell Type Level Pattern Image Note
TS19: left ventricle cardiac muscle fetal cardiomyocyte Present 3K Ctrl LV
Specimen 3K cKO RV: embryonic day 11.5; Lonp1tm1.1Zzy/Lonp1tm1.1Zzy, Tg(Tnnt2-cre)5Blh/0 (more )
Note: Conditional mutant. Double labeled: green - H2ax; red - Tnnt2 (assay MGI:7711946).
Structure Cell Type Level Pattern Image Note
TS19: right ventricle cardiac muscle fetal cardiomyocyte Present 3K cKO RV Significantly increased level of DNA damage (H2ax+) compared with the control.
Specimen 3K cKO LV: embryonic day 11.5; Lonp1tm1.1Zzy/Lonp1tm1.1Zzy, Tg(Tnnt2-cre)5Blh/0 (more )
Note: Conditional mutant. Double labeled: green - H2ax; red - Tnnt2 (assay MGI:7711946).
Structure Cell Type Level Pattern Image Note
TS19: left ventricle cardiac muscle fetal cardiomyocyte Present 3K cKO LV Significantly increased level of DNA damage (H2ax+) compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
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