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Ambp Gene Detail
Summary
  • Symbol
    Ambp
  • Name
    alpha 1 microglobulin/bikunin precursor
  • Synonyms
    ASPI, HI-30, Intin4, Itil, ulinastatin, Urinary Trypsin Inhibitor, UTI
  • Feature Type
    protein coding gene
  • IDs
    MGI:88002
    NCBI Gene: 11699
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63061512-63072409 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.96 cM, cytoband C1-C3
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    481 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88002
 protein coding gene Chr4:63061512-63073036 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028361
 protein coding gene Chr4:62144424-62155931 (-)
A/J MGP_AJ_G0028322
 protein coding gene Chr4:59898852-59910346 (-)
AKR/J MGP_AKRJ_G0028271
 protein coding gene Chr4:61543592-61555115 (-)
BALB/cJ MGP_BALBcJ_G0028342
 protein coding gene Chr4:60065929-60077423 (-)
C3H/HeJ MGP_C3HHeJ_G0028060
 protein coding gene Chr4:62058511-62069949 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028782
 protein coding gene Chr4:64281211-64292727 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026088
 protein coding gene Chr4:57235048-57247293 (-)
CAST/EiJ MGP_CASTEiJ_G0027496
 protein coding gene Chr4:60020809-60032386 (-)
CBA/J MGP_CBAJ_G0028027
 protein coding gene Chr4:66507727-66519258 (-)
DBA/2J MGP_DBA2J_G0028177
 protein coding gene Chr4:59755931-59767467 (-)
FVB/NJ MGP_FVBNJ_G0028142
 protein coding gene Chr4:59006860-59018383 (-)
LP/J MGP_LPJ_G0028274
 protein coding gene Chr4:62410063-62421586 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028169
 protein coding gene Chr4:69611148-69622651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028818
 protein coding gene Chr4:61646348-61657871 (-)
PWK/PhJ MGP_PWKPhJ_G0027223
 protein coding gene Chr4:58240764-58252444 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027052
 protein coding gene Chr4:59112303-59123791 (-)
WSB/EiJ MGP_WSBEiJ_G0027576
 protein coding gene Chr4:61648516-61661383 (-)



Homology
more
  • Human Ortholog
    AMBP, alpha-1-microglobulin/bikunin precursor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMBP, alpha-1-microglobulin/bikunin precursor
  • Synonyms
    A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI
  • Links
    NCBI Gene ID: 259
    neXtProt AC: NX_P02760
    UniProt: P02760

  • Chr Location
    9q32; chr9:114060127-114078328 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human AMBP associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 1 genetic background
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female homozygotes for targeted null mutations exhibit reduced ovulation rates, oocytes lacking a zona pellucida, and a very low fertilization rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    67
  • cDNA Data
    230
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11699 NCBI Gene Model | MGI Sequence Detail 10898 C57BL/6J ±  kb
    transcript NM_007443 RefSeq | MGI Sequence Detail 1234 C57BL/6  
    polypeptide Q07456 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 238
      cDNA 235
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11437, MGD-MRK-11503, MGD-MRK-1291, MGI:2140204
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:2174 Salier JP, et al., Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Genomics. 1992 Sep;14(1):83-8
    • Latest
      J:300210 Bergwik J, et al., Knockout of the radical scavenger alpha1-microglobulin in mice results in defective bikunin synthesis, endoplasmic reticulum stress and increased body weight. Free Radic Biol Med. 2020 Feb 21;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory