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Amy1 Gene Detail
Summary
  • Symbol
    Amy1
  • Name
    amylase 1, salivary
  • Synonyms
    Amy-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88019
    NCBI Gene: 11722
  • Member of
    Amy cluster
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:113349601-113371399 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 49.35 cM
  • Mapping Data
    66 experiments
Strain
Comparison
more
  • SNPs within 2kb
    630 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88019
 protein coding gene Chr3:113349359-113400348 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027799
 protein coding gene Chr3:115349019-115402816 (-)
A/J MGP_AJ_G0027757
 protein coding gene Chr3:111610116-111663820 (-)
AKR/J MGP_AKRJ_G0027723
 protein coding gene Chr3:114383355-114439821 (-)
BALB/cJ MGP_BALBcJ_G0027769
 protein coding gene Chr3:111425429-111479932 (-)
C3H/HeJ MGP_C3HHeJ_G0027500
 protein coding gene Chr3:114756063-114813455 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028215
 protein coding gene Chr3:119576580-119635978 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025554
 protein coding gene Chr3:107442977-107494439 (-)
CAST/EiJ MGP_CASTEiJ_G0026956
 protein coding gene Chr3:114011093-114070307 (-)
CBA/J MGP_CBAJ_G0027475
 protein coding gene Chr3:123671896-123731477 (-)
DBA/2J MGP_DBA2J_G0027616
 protein coding gene Chr3:110864803-110918251 (-)
FVB/NJ MGP_FVBNJ_G0027584
 protein coding gene Chr3:108554209-108604746 (-)
LP/J MGP_LPJ_G0027726
 protein coding gene Chr3:116882221-116943022 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027614
 protein coding gene Chr3:130562607-130588843 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028271
 protein coding gene Chr3:113985539-114039878 (-)
PWK/PhJ MGP_PWKPhJ_G0026682
 protein coding gene Chr3:110453013-110506370 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026504
 protein coding gene Chr3:111973644-112029021 (-)
WSB/EiJ MGP_WSBEiJ_G0027036
 protein coding gene Chr3:114575448-114640099 (-)



Homology
more
  • Human Ortholog
    AMY1A, amylase alpha 1A
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMY2A, amylase alpha 2A
  • Synonyms
    AMY2, PA
  • Links
    NCBI Gene ID: 279
    neXtProt AC: NX_P04746
    UniProt: P04746

  • Chr Location
    1p21.1; chr1:103616651-103625780 (+)  GRCh38
  • Human Ortholog
    AMY2B, amylase alpha 2B
  • Synonyms
    AMY2, AMY3, HXA
  • Links
    NCBI Gene ID: 280
    neXtProt AC: NX_P19961
    UniProt: P19961

  • Chr Location
    1p21.1; chr1:103553815-103579534 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    110
  • cDNA Data
    320
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11722 NCBI Gene Model | MGI Sequence Detail 21799 C57BL/6J ±  kb
    transcript NM_007446 RefSeq | MGI Sequence Detail 1797 ZRU/MplStud  
    polypeptide P00687 UniProt | EBI | MGI Sequence Detail 511 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 332
      Genomic 6
      cDNA 320
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1313, MGD-MRK-1315
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:12977 Sick K, et al., Genetics of amylase isozymes in the mouse. Hereditas. 1964;51:291-296
    • Latest
      J:340404 Bohuslavova R, et al., NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development. Nat Commun. 2023 Sep 9;14(1):5554
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory