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Aplp2 Gene Detail
Summary
  • Symbol
    Aplp2
  • Name
    amyloid beta precursor-like protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88047
    NCBI Gene: 11804
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:31060853-31123111 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 16.66 cM, cytoband A2-B
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1486 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88047
 protein coding gene Chr9:31060853-31123144 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034517
 protein coding gene Chr9:28807571-28873259 (-)
A/J MGP_AJ_G0034495
 protein coding gene Chr9:28115235-28177531 (-)
AKR/J MGP_AKRJ_G0034421
 protein coding gene Chr9:28676442-28742746 (-)
BALB/cJ MGP_BALBcJ_G0034486
 protein coding gene Chr9:27979269-28043741 (-)
C3H/HeJ MGP_C3HHeJ_G0034198
 protein coding gene Chr9:29040289-29103774 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035007
 protein coding gene Chr9:29796832-29863015 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031937
 protein coding gene Chr9:26938463-26998232 (-)
CAST/EiJ MGP_CASTEiJ_G0033521
 protein coding gene Chr9:28895308-28956190 (-)
CBA/J MGP_CBAJ_G0034172
 protein coding gene Chr9:30782567-30848805 (-)
DBA/2J MGP_DBA2J_G0034329
 protein coding gene Chr9:28122984-28185013 (-)
FVB/NJ MGP_FVBNJ_G0034272
 protein coding gene Chr9:27527477-27590287 (-)
LP/J MGP_LPJ_G0034415
 protein coding gene Chr9:29030536-29093743 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034316
 protein coding gene Chr9:32442272-32506763 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035027
 protein coding gene Chr9:28680874-28742305 (-)
PWK/PhJ MGP_PWKPhJ_G0033226
 protein coding gene Chr9:28057546-28119058 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033060
 protein coding gene Chr9:28777388-28841816 (-)
WSB/EiJ MGP_WSBEiJ_G0033636
 protein coding gene Chr9:28424110-28488031 (-)



Homology
more
  • Human Ortholog
    APLP2, amyloid beta precursor like protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APLP2, amyloid beta precursor like protein 2
  • Synonyms
    APLP-2, APPH, APPL2, CDEBP
  • Links
    NCBI Gene ID: 334
    neXtProt AC: NX_Q06481
    UniProt: Q06481

  • Chr Location
    11q24.3; chr11:130068147-130144811 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for two different targeted alleles show embryonic lethality, or viability and fertility with increased copper levels in cerebral cortex and liver. Double knockouts with App show high mortality, reduced growth, and neurological symptoms.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    11
  • cDNA Data
    400
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031996 Ensembl Gene Model | MGI Sequence Detail 62259 C57BL/6J ±  kb
    transcript ENSMUST00000072634 Ensembl | MGI Sequence Detail 3634 Not Applicable  
    polypeptide ENSMUSP00000072428 Ensembl | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000004137 amyloid beta precursor like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR008155 Amyloidogenic glycoprotein
      IPR011178 Amyloidogenic glycoprotein, copper-binding
      IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved site
      IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
      IPR024329 Amyloidogenic glycoprotein, E2 domain
      IPR008154 Amyloidogenic glycoprotein, extracellular
      IPR015849 Amyloidogenic glycoprotein, heparin-binding
      IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
      IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
      IPR019543 Beta-amyloid precursor protein C-terminal
      IPR036176 E2 domain superfamily
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR011993 PH-like domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    • GlyGen
      Q06335 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 409
      Genomic 7
      cDNA 401
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1361, MGI:2143122
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 12
      Gene Ontology 16
      Phenotypes 67
    • Earliest
      J:30521 Clarke L, et al., The structure and function of yeast centromeres. Annu Rev Genet. 1985;19:29-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory