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Asgr2 Gene Detail
Summary
  • Symbol
    Asgr2
  • Name
    asialoglycoprotein receptor 2
  • Synonyms
    ASGPR2, Asgr, Asgr-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88082
    NCBI Gene: 11890
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69983470-69997013 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88082
 protein coding gene Chr11:69983470-69997013 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018581
 protein coding gene Chr11:70602901-70616112 (+)
A/J MGP_AJ_G0018549
 protein coding gene Chr11:67922851-67936054 (+)
AKR/J MGP_AKRJ_G0018518
 protein coding gene Chr11:69944827-69957944 (+)
BALB/cJ MGP_BALBcJ_G0018521
 protein coding gene Chr11:68248734-68261853 (+)
C3H/HeJ MGP_C3HHeJ_G0018334
 protein coding gene Chr11:69985193-69998360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018972
 protein coding gene Chr11:72715189-72728301 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016617
 protein coding gene Chr11:64849558-64864563 (+)
CAST/EiJ MGP_CASTEiJ_G0017889
 protein coding gene Chr11:70237858-70251315 (+)
CBA/J MGP_CBAJ_G0018306
 protein coding gene Chr11:75999504-76012625 (+)
DBA/2J MGP_DBA2J_G0018416
 protein coding gene Chr11:67501955-67515753 (+)
FVB/NJ MGP_FVBNJ_G0018406
 protein coding gene Chr11:67154660-67167760 (+)
LP/J MGP_LPJ_G0018486
 protein coding gene Chr11:71180860-71193981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018429
 protein coding gene Chr11:76569650-76582831 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019014
 protein coding gene Chr11:70221623-70234831 (+)
PWK/PhJ MGP_PWKPhJ_G0017663
 protein coding gene Chr11:68158592-68171896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017453
 protein coding gene Chr11:70024448-70037826 (+)
WSB/EiJ MGP_WSBEiJ_G0017943
 protein coding gene Chr11:69887680-69900921 (+)



Homology
more
  • Human Ortholog
    ASGR2, asialoglycoprotein receptor 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASGR2, asialoglycoprotein receptor 2
  • Synonyms
    ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2
  • Links
    NCBI Gene ID: 433
    neXtProt AC: NX_P07307
    UniProt: P07307

  • Chr Location
    17p13.1; chr17:7101322-7115700 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced ASGR1 protein expression and deficiency in clearance of asialoorsomucoid.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    26
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11890 NCBI Gene Model | MGI Sequence Detail 13544 C57BL/6J ±  kb
    transcript NM_001313925 RefSeq | MGI Sequence Detail 1446 ZRU/MplStud  
    polypeptide P24721 UniProt | EBI | MGI Sequence Detail 301 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1414, MGD-MRK-1416, MGD-MRK-1418
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:312366 Susan-Resiga D, et al., Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin. J Biol Chem. 2021 Sep 8;297(4):101177
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory