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Atp1b2 Gene Detail
Summary
  • Symbol
    Atp1b2
  • Name
    ATPase, Na+/K+ transporting, beta 2 polypeptide
  • Synonyms
    Amog, Atpb-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88109
    NCBI Gene: 11932
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69490562-69496768 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88109
 protein coding gene Chr11:69490554-69496786 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018539
 protein coding gene Chr11:70048347-70054553 (-)
A/J MGP_AJ_G0018507
 protein coding gene Chr11:67413479-67419681 (-)
AKR/J MGP_AKRJ_G0018476
 protein coding gene Chr11:69424063-69430269 (-)
BALB/cJ MGP_BALBcJ_G0018479
 protein coding gene Chr11:67723981-67730187 (-)
C3H/HeJ MGP_C3HHeJ_G0018292
 protein coding gene Chr11:69443355-69449561 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018930
 protein coding gene Chr11:72172905-72179111 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016575
 protein coding gene Chr11:64336422-64342649 (-)
CAST/EiJ MGP_CASTEiJ_G0017847
 protein coding gene Chr11:69687487-69693690 (-)
CBA/J MGP_CBAJ_G0018265
 protein coding gene Chr11:75394324-75400530 (-)
DBA/2J MGP_DBA2J_G0018374
 protein coding gene Chr11:66994853-67001059 (-)
FVB/NJ MGP_FVBNJ_G0018364
 protein coding gene Chr11:66630928-66637134 (-)
LP/J MGP_LPJ_G0018444
 protein coding gene Chr11:70618707-70624913 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018387
 protein coding gene Chr11:75997430-76003636 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018972
 protein coding gene Chr11:69677178-69683380 (-)
PWK/PhJ MGP_PWKPhJ_G0017621
 protein coding gene Chr11:67643795-67650001 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017411
 protein coding gene Chr11:69497194-69503386 (-)
WSB/EiJ MGP_WSBEiJ_G0017901
 protein coding gene Chr11:69353406-69359612 (-)



Homology
more
  • Human Ortholog
    ATP1B2, ATPase Na+/K+ transporting subunit beta 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP1B2, ATPase Na+/K+ transporting subunit beta 2
  • Synonyms
    AMOG
  • Links
    NCBI Gene ID: 482
    neXtProt AC: NX_P14415
    UniProt: P14415

  • Chr Location
    17p13.1; chr17:7646627-7657770 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null mutation exhibit lack of motor coordination, tremors, limb paralysis, enlarged ventricles, photoreceptor degeneration, vacuoles adjoining capillaries of brain stem, thalamus, striatum, and spinal cord, and death at 17-18 days of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    56
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    965
  • Tissues
    151
  • cDNA Data
    67
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041329 Ensembl Gene Model | MGI Sequence Detail 6207 C57BL/6J ±  kb
    transcript ENSMUST00000047889 Ensembl | MGI Sequence Detail 2842 Not Applicable  
    polypeptide ENSMUSP00000047353 Ensembl | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004440 sodium/potassium-transporting ATPase subunit beta-2
      (term hierarchy)
    • InterPro Domains
      IPR000402 Sodium/potassium-transporting ATPase subunit beta
      IPR038702 Sodium/potassium-transporting ATPase subunit beta superfamily
    • GlyGen
      P14231 12 sites, 40 N-linked glycans (10 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 6
      cDNA 70
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1306, MGD-MRK-1461, MGD-MRK-1475
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 13
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory