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Atp4a Gene Detail
Summary
  • Symbol
    Atp4a
  • Name
    ATPase, H+/K+ exchanging, gastric, alpha polypeptide
  • Synonyms
    H+/K+-ATPase alpha, H+K+-transporting alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88113
    NCBI Gene: 11944
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30411634-30424959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.20 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    415 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88113
 protein coding gene Chr7:30411634-30424959 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032040
 protein coding gene Chr7:29718942-29734394 (+)
A/J MGP_AJ_G0032017
 protein coding gene Chr7:28911389-28924772 (+)
AKR/J MGP_AKRJ_G0031950
 protein coding gene Chr7:29652850-29666243 (+)
BALB/cJ MGP_BALBcJ_G0032024
 protein coding gene Chr7:29098395-29111693 (+)
C3H/HeJ MGP_C3HHeJ_G0031743
 protein coding gene Chr7:30108240-30123069 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032490
 protein coding gene Chr7:30686403-30702010 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029540
 protein coding gene Chr7:29934376-29947152 (+)
CAST/EiJ MGP_CASTEiJ_G0031077
 protein coding gene Chr7:23364083-23377514 (+)
CBA/J MGP_CBAJ_G0031709
 protein coding gene Chr7:32136936-32150991 (+)
DBA/2J MGP_DBA2J_G0031861
 protein coding gene Chr7:28639435-28652843 (+)
FVB/NJ MGP_FVBNJ_G0031818
 protein coding gene Chr7:28779671-28792962 (+)
LP/J MGP_LPJ_G0031942
 protein coding gene Chr7:30031434-30047093 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031854
 protein coding gene Chr7:31376937-31391407 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032518
 protein coding gene Chr7:29155028-29168929 (+)
PWK/PhJ MGP_PWKPhJ_G0030801
 protein coding gene Chr7:23680064-23694183 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030636
 protein coding gene Chr7:20165095-20178291 (+)
WSB/EiJ MGP_WSBEiJ_G0031187
 protein coding gene Chr7:29558279-29572670 (+)



Homology
more
  • Human Ortholog
    ATP4A, ATPase H+/K+ transporting subunit alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP4A, ATPase H+/K+ transporting subunit alpha
  • Synonyms
    ATP6A
  • Links
    NCBI Gene ID: 495
    neXtProt AC: NX_P20648
    UniProt: P20648

  • Chr Location
    19q13.12; chr19:35550031-35563658 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 3 alleles in 4 genetic backgrounds
    5 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in achlorhydria, hypergastrinemia, and abnormalities of the parietal cells. Mice homozygous for an ENU-induced allele exhibit iron-deficiency anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    97
  • cDNA Data
    9
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11944 NCBI Gene Model | MGI Sequence Detail 13326 C57BL/6J ±  kb
    transcript NM_001290627 RefSeq | MGI Sequence Detail 3497 ZRU/MplStud  
    polypeptide Q64436 UniProt | EBI | MGI Sequence Detail 1034 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004451 potassium-transporting ATPase alpha chain 1
      (term hierarchy)
    • EC
      7.2.2.19
    • InterPro Domains
      IPR050510 Cation transport ATPase (P-type)
      IPR006068 Cation-transporting P-type ATPase, C-terminal
      IPR004014 Cation-transporting P-type ATPase, N-terminal
      IPR015127 Gastric H+/K+-transporter P-type ATPase, N-terminal
      IPR036412 HAD-like superfamily
      IPR023214 HAD superfamily
      IPR001757 P-type ATPase
      IPR008250 P-type ATPase, A domain superfamily
      IPR023299 P-type ATPase, cytoplasmic domain N
      IPR044492 P-type ATPase, haloacid dehalogenase domain
      IPR018303 P-type ATPase, phosphorylation site
      IPR005775 P-type ATPase subfamily IIC, subunit alpha
      IPR023298 P-type ATPase, transmembrane domain superfamily
    • GlyGen
      Q64436 4 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1466
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:12937 Sayed AK, et al., 64Cu uptake by cultured fibroblasts from Mobr/Y mice. Fed Proc. 1978;37:746 (Abstr.)
    • Latest
      J:344202 Ayasse N, et al., Benzamil-mediated urine alkalization is caused by the inhibition of H(+)-K(+)-ATPases. Am J Physiol Renal Physiol. 2021 Apr 1;320(4):F596-F607
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory