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Atp6v0c Gene Detail
Summary
  • Symbol
    Atp6v0c
  • Name
    ATPase, H+ transporting, lysosomal V0 subunit C
  • Synonyms
    Atp6c2, Atp6l, Atpl, Atpl-rs1, H(+)-ATPase (mvp), PL16, proteolipid
  • Feature Type
    protein coding gene
  • IDs
    MGI:88116
    NCBI Gene: 11984
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24382839-24388652 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88116
 protein coding gene Chr17:24382839-24388676 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023291
 protein coding gene Chr17:23117933-23123468 (-)
A/J MGP_AJ_G0023251
 protein coding gene Chr17:22516745-22522295 (-)
AKR/J MGP_AKRJ_G0023218
 protein coding gene Chr17:22579596-22585153 (-)
BALB/cJ MGP_BALBcJ_G0023256
 protein coding gene Chr17:22693466-22699159 (-)
C3H/HeJ MGP_C3HHeJ_G0023016
 protein coding gene Chr17:22913766-22919589 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023699
 protein coding gene Chr17:24162634-24168579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021175
 protein coding gene Chr17:19976138-19981344 (-)
CAST/EiJ MGP_CASTEiJ_G0022518
 protein coding gene Chr17:22756609-22762088 (-)
CBA/J MGP_CBAJ_G0022992
 protein coding gene Chr17:24989589-24995168 (-)
DBA/2J MGP_DBA2J_G0023121
 protein coding gene Chr17:22090615-22095833 (-)
FVB/NJ MGP_FVBNJ_G0023091
 protein coding gene Chr17:21806514-21812326 (-)
LP/J MGP_LPJ_G0023198
 protein coding gene Chr17:23434149-23441651 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023110
 protein coding gene Chr17:24708223-24713956 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023737
 protein coding gene Chr17:22846394-22852618 (-)
PWK/PhJ MGP_PWKPhJ_G0022267
 protein coding gene Chr17:20848252-20854307 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022085
 protein coding gene Chr17:20871472-20876724 (-)
WSB/EiJ MGP_WSBEiJ_G0022581
 protein coding gene Chr17:22911220-22918383 (-)



Homology
more
  • Human Ortholog
    ATP6V0C, ATPase H+ transporting V0 subunit c
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP6V0C, ATPase H+ transporting V0 subunit c
  • Synonyms
    ATP6C, ATP6L, ATPL, EPEO3, VATL, Vma3, VPPC
  • Links
    NCBI Gene ID: 527
    neXtProt AC: NX_P27449
    UniProt: P27449

  • Chr Location
    16p13.3; chr16:2513726-2520218 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ATP6V0C associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1015
  • Tissues
    156
  • cDNA Data
    27
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11984 NCBI Gene Model | MGI Sequence Detail 5814 C57BL/6J ±  kb
    transcript NM_001361534 RefSeq | MGI Sequence Detail 1243 C57BL/6  
    polypeptide P63082 UniProt | EBI | MGI Sequence Detail 155 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 29
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1476, MGD-MRK-36190, MGD-MRK-36468, MGI:107616
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:20078 Hanada H, et al., Molecular cloning of cDNA encoding the 16 KDa subunit of vacuolar H(+)-ATPase from mouse cerebellum. Biochem Biophys Res Commun. 1991 May 15;176(3):1062-7
    • Latest
      J:341383 Salamon I, et al., Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nat Commun. 2023 Sep 27;14(1):6025
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory