About   Help   FAQ
Tspo Gene Detail
Summary
  • Symbol
    Tspo
  • Name
    translocator protein
  • Synonyms
    Bzrp, PBR, Tspo1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88222
    NCBI Gene: 12257
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:83447793-83458404 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    433 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88222
 protein coding gene Chr15:83447774-83458404 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022167
 protein coding gene Chr15:84273466-84288799 (+)
A/J MGP_AJ_G0022126
 protein coding gene Chr15:81187899-81198531 (+)
AKR/J MGP_AKRJ_G0022101
 protein coding gene Chr15:83552212-83562848 (+)
BALB/cJ MGP_BALBcJ_G0022132
 protein coding gene Chr15:81330691-81341100 (+)
C3H/HeJ MGP_C3HHeJ_G0021902
 protein coding gene Chr15:83508823-83521272 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022577
 protein coding gene Chr15:87524575-87536445 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020102
 protein coding gene Chr15:77564702-77575412 (+)
CAST/EiJ MGP_CASTEiJ_G0021424
 protein coding gene Chr15:84278812-84290869 (+)
CBA/J MGP_CBAJ_G0021869
 protein coding gene Chr15:90289882-90303257 (+)
DBA/2J MGP_DBA2J_G0021996
 protein coding gene Chr15:80672479-80683502 (+)
FVB/NJ MGP_FVBNJ_G0021975
 protein coding gene Chr15:79716941-79728059 (+)
LP/J MGP_LPJ_G0022067
 protein coding gene Chr15:84447865-84458443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021995
 protein coding gene Chr15:95189117-95202709 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022592
 protein coding gene Chr15:83551725-83566134 (+)
PWK/PhJ MGP_PWKPhJ_G0021165
 protein coding gene Chr15:80664650-80676153 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020999
 protein coding gene Chr15:83284465-83297024 (+)
WSB/EiJ MGP_WSBEiJ_G0021473
 protein coding gene Chr15:84053714-84066121 (+)



Homology
more
  • Human Ortholog
    TSPO, translocator protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPO, translocator protein
  • Synonyms
    BPBS, BZRP, DBI, IBP, MBR, mDRC, PBR, PBS, pk18, PKBS, PTBR, TSPO1
  • Links
    NCBI Gene ID: 706
    neXtProt AC: NX_P30536
    UniProt: P30536

  • Chr Location
    22q13.2; chr22:43151547-43163242 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 5 genetic backgrounds
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    5
  • Gene trapped
    10
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    11
  • Genomic Mutations
    3 involving Tspo
  • Find Mice (IMSR)
    16 strains or lines available
Mice homozygous for a conditional allele activated in the male reproductive system exhibit normal testicular development, reproduction and testosterone production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    997
  • Tissues
    194
  • cDNA Data
    177
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041736 Ensembl Gene Model | MGI Sequence Detail 10612 C57BL/6J ±  kb
transcript ENSMUST00000047419 Ensembl | MGI Sequence Detail 837 Not Applicable  
polypeptide ENSMUSP00000037039 Ensembl | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 184
    cDNA 177
    Primer pair 5
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1694
References
more
  • Summaries
    All 124
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 8
    Phenotypes 62
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:347651 Firth W, et al., Regulation of astrocyte metabolism by mitochondrial translocator protein 18 kDa. J Neurochem. 2024 Mar 14;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory