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C5ar1 Gene Detail
Summary
  • Symbol
    C5ar1
  • Name
    complement component 5a receptor 1
  • Synonyms
    C5aR, C5r1, Cd88, D7Msu1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88232
    NCBI Gene: 12273
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15980668-15993465 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.77 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88232
 protein coding gene Chr7:15980668-15993465 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031704
 protein coding gene Chr7:13916240-13930319 (-)
A/J MGP_AJ_G0031676
 protein coding gene Chr7:13712413-13726383 (-)
AKR/J MGP_AKRJ_G0031601
 protein coding gene Chr7:14016157-14032421 (-)
BALB/cJ MGP_BALBcJ_G0031683
 protein coding gene Chr7:13808273-13820954 (-)
C3H/HeJ MGP_C3HHeJ_G0031405
 protein coding gene Chr7:14192874-14207594 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032149
 protein coding gene Chr7:14667910-14681323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029228
 protein coding gene Chr7:15269356-15281551 (-)
CAST/EiJ MGP_CASTEiJ_G0030756
 protein coding gene Chr7:10962570-10978013 (-)
CBA/J MGP_CBAJ_G0031364
 protein coding gene Chr7:15136887-15152107 (-)
DBA/2J MGP_DBA2J_G0031520
 protein coding gene Chr7:13595933-13609281 (-)
FVB/NJ MGP_FVBNJ_G0031476
 protein coding gene Chr7:13488637-13503076 (-)
LP/J MGP_LPJ_G0031605
 protein coding gene Chr7:14183413-14195689 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031511
 protein coding gene Chr7:15104123-15118742 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032178
 protein coding gene Chr7:13795488-13809606 (-)
PWK/PhJ MGP_PWKPhJ_G0030480
 protein coding gene Chr7:11104457-11124531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030307
 protein coding gene Chr7:8726316-8738072 (-)
WSB/EiJ MGP_WSBEiJ_G0030853
 protein coding gene Chr7:13849804-13866863 (-)



Homology
more
  • Human Ortholog
    C5AR1, complement C5a receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C5AR1, complement C5a receptor 1
  • Synonyms
    C5A, C5AR, C5R1, CD88
  • Links
    NCBI Gene ID: 728
    neXtProt AC: NX_P21730
    UniProt: P21730

  • Chr Location
    19q13.32; chr19:47290023-47322066 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 6 genetic backgrounds
    15 phenotypes from multigenic genotypes
    183 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants have impaired C5 responses that can show increased or decreased acute inflammation under different circumstances, and thus affect severity of disease or infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    29
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12273 NCBI Gene Model | MGI Sequence Detail 12798 C57BL/6J ±  kb
    transcript NM_001173550 RefSeq | MGI Sequence Detail 2540 ZRU/MplStud  
    polypeptide P30993 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 10
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1710, MGI:2180152
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 183
    • Earliest
      J:2871 Gerard C, et al., Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol. 1992 Oct 15;149(8):2600-6
    • Latest
      J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/05/2024
    MGI 6.24     		The Jackson Laboratory